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1000 Titel
  • Role of high-resolution ultrasound in detection and monitoring of peripheral nerve tumor burden in neurofibromatosis in children
1000 Autor/in
  1. Winter, Natalie |
  2. Dohrn, Maike F. |
  3. Wittlinger, Julia |
  4. Loizides, Alexander |
  5. Gruber, Hannes |
  6. Grimm, Alexander |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-06-19
1000 Erschienen in
1000 Quellenangabe
  • 36(10):2427-2432
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s00381-020-04718-z |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7575466/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Purpose!#!Peripheral nerve sheath tumors are hallmark findings in neurofibromatosis types 1 and 2. With increasing size, they typically lead to neurological symptoms, and NF1 patients have a lifetime risk of 8-13% for developing malignant peripheral nerve sheath tumors. Medical imaging is therefore highly needed for early detection and exact localization of symptomatic or potentially malignant tumors. This review will give an overview of the ultrasound characteristics of peripheral nerve sheath tumors and findings in patients with neurofibromatosis types 1 and 2.!##!Methods!#!A systematic search of electronic databases, reference lists, and unpublished literature was conducted including the keywords 'schwannoma,' 'neurofibroma,' 'neurofibromatosis,' 'benign and malignant peripheral nerve sheath tumor.'!##!Results!#!The high-resolution allows a clear analysis of tumor echotexture, definition of margins, and the relation to the parent nerve. The use of color duplex/Doppler and contrast agent adds valuable information for the differentiation of benign and malignant tumors.!##!Conclusion!#!High-resolution ultrasound is a well-established, non-invasive, and easily repeatable first-line tool in diagnostic procedures of soft tissue tumors.
1000 Sacherschließung
lokal Annual Issue Paper
lokal Neurofibroma
lokal High resolution nerve ultrasound
lokal Humans [MeSH]
lokal Neurofibroma [MeSH]
lokal Neurilemmoma/diagnostic imaging [MeSH]
lokal Nerve Sheath Neoplasms/diagnostic imaging [MeSH]
lokal Schwannoma
lokal Child [MeSH]
lokal Peripheral Nervous System Neoplasms/diagnostic imaging [MeSH]
lokal Neurofibromatosis
lokal Neurofibromatosis 1/diagnostic imaging [MeSH]
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