Three-dimensional Monte Carlo-based voxel-wise tumor dosimetry in patients with neuroendocrine tumors who underwent 177Lu-DOTATOC therapy

  1. Goetz, Th. I.
  2. Lang, E. W.
  3. Prante, O.
  4. Maier, A.
  5. Cordes, M.
  6. Kuwert, T.
  7. Ritt, P.
  8. Schmidkonz, Christian ORCID logo

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1000 Titel
  • Three-dimensional Monte Carlo-based voxel-wise tumor dosimetry in patients with neuroendocrine tumors who underwent 177Lu-DOTATOC therapy
1000 Autor/in
  1. Goetz, Th. I. |
  2. Lang, E. W. |
  3. Prante, O. |
  4. Maier, A. |
  5. Cordes, M. |
  6. Kuwert, T. |
  7. Ritt, P. |
  8. Schmidkonz, Christian |
1000 Erscheinungsjahr 2020
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2020-02-29
1000 Erschienen in
1000 Quellenangabe
  • 34(4):244-253
1000 Copyrightjahr
  • 2020
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1007/s12149-020-01440-3 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101301/ |
1000 Publikationsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Background!#!Patients with advanced neuroendocrine tumors (NETs) of the midgut are suitable candidates for !##!Methods!#!A cohort of 14 patients with histologically confirmed metastasized NETs of the midgut (11 men, 3 women, 62.3 ± 11.0 years of age) underwent a total of 39 cycles of !##!Results!#!The average dose values per cycle were 3.41 ± 1.28 Gy (1.91-6.22 Gy) for the kidneys, 4.40 ± 2.90 Gy (1.14-11.22 Gy) for the spleen, and 9.70 ± 8.96 Gy (1.47-39.49 Gy) for all !##!Conclusion!#!These results suggest that Monte Carlo-based voxel-wise dosimetry is a very promising tool for predicting the absorbed TTD based on histological and clinical parameters.
1000 Sacherschließung
lokal Chromogranin A/radiation effects [MeSH]
lokal Aged [MeSH]
lokal Organometallic Compounds/pharmacokinetics [MeSH]
lokal Radiometry [MeSH]
lokal Antineoplastic Agents/administration
lokal Octreotide/administration
lokal Original Article
lokal Radioisotopes/administration
lokal Male [MeSH]
lokal Radioisotopes/pharmacokinetics [MeSH]
lokal Neuroendocrine Tumors/radiotherapy [MeSH]
lokal Single Photon Emission Computed Tomography Computed Tomography [MeSH]
lokal Octreotide/analogs
lokal Organometallic Compounds/administration
lokal Female [MeSH]
lokal Monte Carlo simulations
lokal Octreotide/chemistry [MeSH]
lokal Radiopharmaceuticals/pharmacokinetics [MeSH]
lokal Humans [MeSH]
lokal Lutetium/pharmacokinetics [MeSH]
lokal Treatment Outcome [MeSH]
lokal Middle Aged [MeSH]
lokal Organometallic Compounds/pharmacology [MeSH]
lokal Lutetium/administration
lokal Dosimetry
lokal Neuroendocrine tumors
lokal Antineoplastic Agents/pharmacokinetics [MeSH]
lokal Radiopharmaceuticals/administration
lokal Octreotide/pharmacokinetics [MeSH]
lokal Radiotherapy Dosage [MeSH]
lokal Monte Carlo Method [MeSH]
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/uri/R29ldHosIFRoLiBJLg==|https://frl.publisso.de/adhoc/uri/TGFuZywgRS4gVy4=|https://frl.publisso.de/adhoc/uri/UHJhbnRlLCBPLg==|https://frl.publisso.de/adhoc/uri/TWFpZXIsIEEu|https://frl.publisso.de/adhoc/uri/Q29yZGVzLCBNLg==|https://frl.publisso.de/adhoc/uri/S3V3ZXJ0LCBULg==|https://frl.publisso.de/adhoc/uri/Uml0dCwgUC4=|https://orcid.org/0000-0002-1988-0058
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1000 Erstellt am 2023-11-18T13:42:22.473+0100
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