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Functional relevance of in vivo half antibody exchange of an IgG4 therapeutic antibody-drug conjugate

2018 . Herbener, Peter | Schönfeld, Kurt | König, Martin | Germer, Matthias | Przyborski, Jude M. | Bernöster, Katrin | Schüttrumpf, Jörg

Parallel PI3K, AKT and mTOR inhibition is required to control feedback loops that limit tumor therapy

2018 . Sathe, Anuja | Chalaud, Géraldine | Oppolzer, Immanuel | Wong, Kit Yeng | von Busch, Margarita | Schmid, Sebastian C. | Tong, Zhichao | Retz, Margitta | Gschwend, Juergen E. | Schulz, Wolfgang A. | Nawroth, Roman

A mouse model for evaluation of efficacy and concomitant toxicity of anti-human CXCR4 therapeutics

2018 . Costa, Maria José | Kudaravalli, Jyothirmayee | Liu, Wen-Hui | Stock, Jeffrey | Kong, Sophanna | Liu, Shu-Hui

MMP-9 inhibition promotes anti-tumor immunity through disruption of biochemical and physical barriers to T-cell trafficking to tumors

2018 . Juric, Vladi | O'Sullivan, Chris | Stefanutti, Erin | Kovalenko, Maria | Greenstein, Andrew | Barry-Hamilton, Vivian | Mikaelian, Igor | Degenhardt, Jeremiah | Yue, Peng | Smith, Victoria | Mikels-Vigdal, Amanda

T cell mediated immunity after combination therapy with intralesional PV-10 and blockade of the PD-1/PD-L1 pathway in a murine melanoma model

2018 . Liu, Hao | Weber, Amy | Morse, Jennifer | Kodumudi, Krithika | Scott, Ellen | Mullinax, John | Sarnaik, Amod A. | Pilon-Thomas, Shari