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In vitro to in vivo acetaminophen hepatotoxicity extrapolation using classical schemes, pharmacodynamic models and a multiscale spatial-temporal liver twin

2023 . Dichamp, Jules | Celliere, Géraldine | Ghallab, Ahmed | hassan, reham | Boissier, Noemie | Hofmann, Ute | Reinders, Joerg | Sezgin, Selahaddin | Zuehlke, Sebastian | Hengstler, Jan | Drasdo, Dirk

PBTK modeling of the pyrrolizidine alkaloid retrorsine to predict liver toxicity in mouse and rat

2023 . Lehmann, Anja | Geburek, Ina | These, Anja | Hessel-Pras, Stefanie | Hengstler, Jan | Albrecht, Wiebke | Mielke, Hans | Müller-Graf, Christine | Yang, Xiaojing | Kloft, Charlotte | Hethey, Christoph

1GaoflJ, et al. J Immunother Cancer 2023;11:e006704. doi:10.1136/jitc-2023-006704 Open access CLDN18.2 and 4-1BB bispecific antibody givastomig exerts antitumor activity through CLDN18.2-expressing tumor- directed T- cell activation

2023 . Jing Gao | Zhengyi Wang | Wenqing Jiang | Yanni Zhang | Zhen Meng | Yanling Niu | Zhen Sheng | Chan Chen | Xuejun Liu | Xi Chen | Chanjuan Liu | Jia, Keren | Cheng Zhang | Haiyan Liao | Jaeho Jung | Eunsil Sung | Hyejin Chung | Jingwu Z. Zhang | Andrew X. Zhu | Shen, Lin

Metabolomics-based strategy to assess drug hepatotoxicity and uncover the mechanisms of hepatotoxicity involved

2023 . Martínez-Sena, Teresa | Moro,Erika | Moreno-Torres, Marta | Quintás, Guillermo | Hengstler, Jan | Castell, Jose V.