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NEMO/NF-κB signaling functions as a double-edged sword in PanIN formation versus progression to pancreatic cancer

2024 . Tsesmelis, Miltiadis | Büttner, Ulrike F. G. | Gerstenlauer, Melanie | Manfras, Uta | Tsesmelis, Konstantinos | Du, Ziwei | Sperb, Nadine | Weissinger, Stephanie Ellen | Möller, Peter | Barth, Thomas F. E. | Maier, Harald J. | Chan, Lap Kwan | Wirth, Thomas

An expedited screening platform for the discovery of anti-ageing compounds in vitro and in vivo

2024 . Lujan, Celia | Tyler, Eleanor Jane | Ecker, Simone | Webster, Amy Philomena | Stead, Eleanor Rachel | Martinez-Miguel, Victoria Eugenia | Milligan, Deborah | Garbe, James Charles | Stampfer, Martha Ruskin | Beck, Stephan | Lowe, Robert | Bishop, Cleo Lucinda | Bjedov, Ivana

Biochemical and transcriptomic evaluation of a 3D lung organoid platform for pre-clinical testing of active substances targeting senescence

2024 . Brand, Michelle | Ritzmann, Felix | Kattler, Kathrin | Milasius, Deivydas | Yao, Yiwen | Herr, Christian | Kirsch, Susanne H. | Müller, Rolf | Yildiz, Daniela | Bals, Robert | Beisswenger, Christoph

Cell-autonomous IL6ST activation suppresses prostate cancer development via STAT3/ARF/p53-driven senescence and confers an immune-active tumor microenvironment