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Impact of therapeutic inhibition of oncogenic cell signaling tyrosine kinase on cell metabolism: in vivo-detectable metabolic biomarkers of inhibition

2024 . Nath, Kavindra | Gupta, Pradeep K. | Basappa, Johnvesly | Wang, Shengchun | Sen, Neil | Lobello, Cosimo | Tomar, Jyoti S. | Shestov, Alexander A. | Orlovskiy, Stepan | Arias-Mendoza, Fernando | Rauert-Wunderlich, Hilka | Nelson, David S. | Glickson, Jerry D. | Wasik, Mariusz A.

Targeting CXCR4/CXCL12 axis via [177Lu]Lu-DOTAGA.(SA.FAPi)2 with CXCR4 antagonist in triple-negative breast cancer

2024 . Bao, Guangfa | Wang, Ziqiang | Liu, Luoxia | Zhang, Buchuan | Song, Shuang | Wang, Dongdong | Cheng, Siyuan | Moon, Eu-Song | Roesch, Frank | Zhao, Jun | Yu, Bo | Zhu, Xiaohua

Rebound growth of BRAF mutant pediatric glioma cells after MAPKi withdrawal is associated with MAPK reactivation and secretion of microglia-recruiting cytokines

Pharmacokinetic–pharmacodynamic guided optimisation of dose and schedule of CGM097, an HDM2 inhibitor, in preclinical and clinical studies

The hepatokine fetuin-A disrupts functional maturation of pancreatic beta cells

Macrophage migration inhibitory factor is regulated by HIF-1α and cAMP and promotes renal cyst cell proliferation in a macrophage-independent manner

2020 . Safi, Wajima | Kraus, Andre | Grampp, Steffen | Schödel, Johannes | Buchholz, Bjoern

Raloxifene inhibits pancreatic adenocarcinoma growth by interfering with ERβ and IL-6/gp130/STAT3 signaling

2020 . Pozios, Ioannis | Seel, Nina N. | Hering, Nina A. | Hartmann, Lisa | Liu, Verena | Camaj, Peter | Müller, Mario H. | Lee, Lucas D. | Bruns, Christiane J. | Kreis, Martin E. | Seeliger, Hendrik

GM-CSF induces noninflammatory proliferation of microglia and disturbs electrical neuronal network rhythms in situ

2020 . Dikmen, Onur | Hemmerich, Marc | Lewen, Andrea | hollnagel, jan-oliver | Chausse, Bruno | Kann, Oliver

Chronic activation of GPR40 does not negatively impact upon BRIN-BD11 pancreatic β-cell physiology and function

2020 . Vilas-Boas, Eloisa Aparecida | Karabacz, Noémie | Marsiglio-Librais, Gabriela Nunes | Valle, Maíra Melo Rezende | Nalbach, Lisa | Ampofo, Emmanuel | Morgan, Bruce | Carpinelli, Angelo Rafael | Roma, Leticia Prates

Inhibition of macrophage proliferation dominates plaque regression in response to cholesterol lowering