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Tumor Treating Fields (TTFields) combined with the drug repurposing approach CUSP9v3 induce metabolic reprogramming and synergistic anti-glioblastoma activity in vitro

2024 . Cao, Qiyu | Hajosch, Annika | Kast, Richard Eric | Loehmann, Christopher | Hlavac, Michal | Fischer-Posovszky, Pamela | Strobel, Hannah | Westhoff, Mike-Andrew | Siegelin, Markus D. | Wirtz, Christian Rainer | Halatsch, Marc-Eric | Karpel-Massler, Georg

Metabolic heterogeneity affects trastuzumab response and survival in HER2-positive advanced gastric cancer

2024 . Wang, Jun | Sun, Na | Kunzke, Thomas | Shen, Jian | Feuchtinger, Annette | Wang, Qian | Meixner, Raphael | Gleut, Ronan Le | Haffner, Ivonne | Luber, Birgit | Lordick, Florian | Walch, Axel Karl

Targeting the glutamine metabolism to suppress cell proliferation in mesenchymal docetaxel-resistant prostate cancer

2024 . Beier, Alicia-Marie K. | Ebersbach, Celina | Siciliano, Tiziana | Scholze, Jana | Hofmann, Jörg | Hönscheid, Pia | Baretton, Gustavo B. | Woods, Kevin | Guezguez, Borhane | Dubrovska, Anna | Markowitsch, Sascha D. | Thomas, Christian | Puhr, Martin | Erb, Holger

Proteomic profiling reveals ACSS2 facilitating metabolic support in acute myeloid leukemia

Combined inhibition of EZH2 and CDK4/6 perturbs endoplasmic reticulum-mitochondrial homeostasis and increases antitumor activity against glioblastoma

The RORɣ/SREBP2 pathway is a master regulator of cholesterol metabolism and serves as potential therapeutic target in t(4;11) leukemia

2023 . Erkner, Estelle | Hentrich, Thomas | Schairer, Rebekka | Fitzel, Rahel | Secker-Grob, Kathy-Ann | Jeong, Johan | Keppeler, Hildegard | Korkmaz, Fulya | Schulze-Hentrich, Julia M. | Lengerke, Claudia | Schneidawind, Dominik | Schneidawind, Corina