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Nanoformulation of dasatinib cannot overcome therapy resistance of pancreatic cancer cells with low LYN kinase expression

2024 . Kaul, Marilyn | Sanin, Ahmed Y. | Shi, Wenjie | Janiak, Christoph | Kahlert, Ulf Dietrich

Pharmacokinetic–pharmacodynamic guided optimisation of dose and schedule of CGM097, an HDM2 inhibitor, in preclinical and clinical studies

The hepatokine fetuin-A disrupts functional maturation of pancreatic beta cells

Pharmaceutical immunoglobulin G impairs anti-carcinoma activity of oxaliplatin in colon cancer cells

2021 . Shang, Yuru | Zhang, Xianbin | Lu, Lili | Jiang, Ke | Krohn, Mathias | Matschos, Stephanie | Mullins, Christina Susanne | Vollmar, Brigitte | Zechner, Dietmar | Gong, Peng | Linnebacher, Michael

Entry and exit of chemotherapeutically-promoted cellular dormancy in glioblastoma cells is differentially affected by the chemokines CXCL12, CXCL16, and CX3CL1

2020 . Adamski, Vivian | Hattermann, Kirsten | Kubelt, Carolin | Cohrs, Gesa | Lucius, Ralph | Synowitz, Michael | Sebens, Susanne | Held-Feindt, Janka

Chronic activation of GPR40 does not negatively impact upon BRIN-BD11 pancreatic β-cell physiology and function

2020 . Vilas-Boas, Eloisa Aparecida | Karabacz, Noémie | Marsiglio-Librais, Gabriela Nunes | Valle, Maíra Melo Rezende | Nalbach, Lisa | Ampofo, Emmanuel | Morgan, Bruce | Carpinelli, Angelo Rafael | Roma, Leticia Prates

CDK4/6 inhibition presents as a therapeutic option for paediatric and adult germ cell tumours and induces cell cycle arrest and apoptosis via canonical and non-canonical mechanisms

2020 . Skowron, Margaretha A. | Vermeulen, Marieke | Winkelhausen, Anna | Becker, Teresa K. | Bremmer, Felix | Petzsch, Patrick | Schönberger, Stefan | Calaminus, Gabriele | Köhrer, Karl | Albers, Peter | Nettersheim, Daniel

Serine-dependent redox homeostasis regulates glioblastoma cell survival

2020 . Engel, Anna L. | Lorenz, Nadja I. | Klann, Kevin | Münch, Christian | Depner, Cornelia | Steinbach, Joachim P. | Ronellenfitsch, Michael W. | Luger, Anna-Luisa