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Impact of therapeutic inhibition of oncogenic cell signaling tyrosine kinase on cell metabolism: in vivo-detectable metabolic biomarkers of inhibition

2024 . Nath, Kavindra | Gupta, Pradeep K. | Basappa, Johnvesly | Wang, Shengchun | Sen, Neil | Lobello, Cosimo | Tomar, Jyoti S. | Shestov, Alexander A. | Orlovskiy, Stepan | Arias-Mendoza, Fernando | Rauert-Wunderlich, Hilka | Nelson, David S. | Glickson, Jerry D. | Wasik, Mariusz A.

Targeting cancer-associated fibroblasts/tumor cells cross-talk inhibits intrahepatic cholangiocarcinoma progression via cell-cycle arrest

2024 . Mancarella, Serena | Gigante, Isabella | Pizzuto, Elena | Serino, Grazia | Terzi, Alberta | Dituri, Francesco | Maiorano, Eugenio | Vincenti, Leonardo | De Bellis, Mario | Ardito, Francesco | Calvisi, Diego F. | Giannelli, Gianluigi

Rebound growth of BRAF mutant pediatric glioma cells after MAPKi withdrawal is associated with MAPK reactivation and secretion of microglia-recruiting cytokines

Drug prioritization identifies panobinostat as a tailored treatment element for patients with metastatic hepatoblastoma

2024 . Demir, Salih | Hotes, Alina | Schmid, Tanja | Cairo, Stefano | Indersie, Emilie | Pisano, Claudio | Hiyama, Eiso | Hishiki, Tomoro | Vokuhl, Christian | Branchereau, Sophie | Brock, Penelope | Schmid, Irene | Zsiros, József | Kappler, Roland

Pharmacokinetic–pharmacodynamic guided optimisation of dose and schedule of CGM097, an HDM2 inhibitor, in preclinical and clinical studies

Pharmaceutical immunoglobulin G impairs anti-carcinoma activity of oxaliplatin in colon cancer cells

2021 . Shang, Yuru | Zhang, Xianbin | Lu, Lili | Jiang, Ke | Krohn, Mathias | Matschos, Stephanie | Mullins, Christina Susanne | Vollmar, Brigitte | Zechner, Dietmar | Gong, Peng | Linnebacher, Michael

EGFRvIII upregulates DNA mismatch repair resulting in increased temozolomide sensitivity of MGMT promoter methylated glioblastoma

Nintedanib and a bi-specific anti-VEGF/Ang2 nanobody selectively prevent brain metastases of lung adenocarcinoma cells

2020 . Kovalchuk, Bogdana | Berghoff, Anna S. | Karreman, Matthia A. | Frey, Katharina | Piechutta, Manuel | Fischer, Manuel | Grosch, Julia | Heiland, Sabine | Breckwoldt, Michael O. | Hilberg, Frank | Wick, Wolfgang | Winkler, Frank

Raloxifene inhibits pancreatic adenocarcinoma growth by interfering with ERβ and IL-6/gp130/STAT3 signaling

2020 . Pozios, Ioannis | Seel, Nina N. | Hering, Nina A. | Hartmann, Lisa | Liu, Verena | Camaj, Peter | Müller, Mario H. | Lee, Lucas D. | Bruns, Christiane J. | Kreis, Martin E. | Seeliger, Hendrik

Adaptive ERK signalling activation in response to therapy and in silico prognostic evaluation of EGFR-MAPK in HNSCC

2020 . Rong, Chao | Muller, Marie F. | Xiang, Fang | Jensen, Alexandra | Weichert, Wilko | Major, Gerald | Plinkert, Peter K. | Hess, Jochen | Affolter, Annette

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