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Targeting CXCR4/CXCL12 axis via [177Lu]Lu-DOTAGA.(SA.FAPi)2 with CXCR4 antagonist in triple-negative breast cancer

2024 . Bao, Guangfa | Wang, Ziqiang | Liu, Luoxia | Zhang, Buchuan | Song, Shuang | Wang, Dongdong | Cheng, Siyuan | Moon, Eu-Song | Roesch, Frank | Zhao, Jun | Yu, Bo | Zhu, Xiaohua

Pharmacokinetic–pharmacodynamic guided optimisation of dose and schedule of CGM097, an HDM2 inhibitor, in preclinical and clinical studies

CDK4/6 inhibition presents as a therapeutic option for paediatric and adult germ cell tumours and induces cell cycle arrest and apoptosis via canonical and non-canonical mechanisms

2020 . Skowron, Margaretha A. | Vermeulen, Marieke | Winkelhausen, Anna | Becker, Teresa K. | Bremmer, Felix | Petzsch, Patrick | Schönberger, Stefan | Calaminus, Gabriele | Köhrer, Karl | Albers, Peter | Nettersheim, Daniel

Separase activity distribution can be a marker of major molecular response and proliferation of CD34+ cells in TKI-treated chronic myeloid leukemia patients

2020 . Spiess, Birgit | Kleiner, Helga | Flach, Johanna | Fabarius, Alice | Saussele, Susanne | Hofmann, Wolf-Karsten | Seifarth, Wolfgang

Inhibition of macrophage proliferation dominates plaque regression in response to cholesterol lowering