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Pharmacokinetic–pharmacodynamic guided optimisation of dose and schedule of CGM097, an HDM2 inhibitor, in preclinical and clinical studies

Pharmaceutical immunoglobulin G impairs anti-carcinoma activity of oxaliplatin in colon cancer cells

2021 . Shang, Yuru | Zhang, Xianbin | Lu, Lili | Jiang, Ke | Krohn, Mathias | Matschos, Stephanie | Mullins, Christina Susanne | Vollmar, Brigitte | Zechner, Dietmar | Gong, Peng | Linnebacher, Michael

Raloxifene inhibits pancreatic adenocarcinoma growth by interfering with ERβ and IL-6/gp130/STAT3 signaling

2020 . Pozios, Ioannis | Seel, Nina N. | Hering, Nina A. | Hartmann, Lisa | Liu, Verena | Camaj, Peter | Müller, Mario H. | Lee, Lucas D. | Bruns, Christiane J. | Kreis, Martin E. | Seeliger, Hendrik

GM-CSF induces noninflammatory proliferation of microglia and disturbs electrical neuronal network rhythms in situ

2020 . Dikmen, Onur | Hemmerich, Marc | Lewen, Andrea | hollnagel, jan-oliver | Chausse, Bruno | Kann, Oliver

CDK4/6 inhibition presents as a therapeutic option for paediatric and adult germ cell tumours and induces cell cycle arrest and apoptosis via canonical and non-canonical mechanisms

2020 . Skowron, Margaretha A. | Vermeulen, Marieke | Winkelhausen, Anna | Becker, Teresa K. | Bremmer, Felix | Petzsch, Patrick | Schönberger, Stefan | Calaminus, Gabriele | Köhrer, Karl | Albers, Peter | Nettersheim, Daniel

Separase activity distribution can be a marker of major molecular response and proliferation of CD34+ cells in TKI-treated chronic myeloid leukemia patients

2020 . Spiess, Birgit | Kleiner, Helga | Flach, Johanna | Fabarius, Alice | Saussele, Susanne | Hofmann, Wolf-Karsten | Seifarth, Wolfgang