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Influence of CYP2D6 Phenotypes on the Pharmacokinetics of Aripiprazole and Dehydro-Aripiprazole Using a Physiologically Based Pharmacokinetic Approach

2021 . Kneller, Lisa Alina | Zubiaur, Pablo | Koller, Dora | Abad-Santos, Francisco | Hempel, Georg

Perpetrator Characteristics of Azole Antifungal Drugs on Three Oral Factor Xa Inhibitors Administered as a Microdosed Cocktail

2021 . Rohr, Brit Silja | Foerster, Kathrin Isabelle | Blank, Antje | Burhenne, Jürgen | Mahmoudi, Mazyar | Haefeli, Walter Emil | Mikus, Gerd

Comparative Plasma and Interstitial Tissue Fluid Pharmacokinetics of Meropenem Demonstrate the Need for Increasing Dose and Infusion Duration in Obese and Non-obese Patients

2021 . Busse, David | Simon, Philipp | Schmitt, Lisa | Petroff, David | Dorn, Christoph | Dietrich, Arne | Zeitlinger, Markus | Huisinga, Wilhelm | Michelet, Robin | Wrigge, Hermann | Kloft, Charlotte

Comprehensive Parent–Metabolite PBPK/PD Modeling Insights into Nicotine Replacement Therapy Strategies

2020 . Kovar, Lukas | Selzer, Dominik | Britz, Hannah | Benowitz, Neal | St. Helen, Gideon | Kohl, Yvonne | Bals, Robert | Lehr, Thorsten

Oral Yohimbine as a New Probe Drug to Predict CYP2D6 Activity: Results of a Fixed-Sequence Phase I Trial

2020 . Vay, Manuela | Meyer, Marleen Julia | Blank, Antje | Skopp, Gisela | Rose, Peter | Tzvetkov, Mladen Vassilev | Mikus, Gerd

Effective Removal of Dabigatran by Idarucizumab or Hemodialysis: A Physiologically Based Pharmacokinetic Modeling Analysis

2020 . Fuhr, Laura Maria | Hanke, Nina | Meibohm, Bernd | Lehr, Thorsten

A Comprehensive Whole-Body Physiologically Based Pharmacokinetic Drug–Drug–Gene Interaction Model of Metformin and Cimetidine in Healthy Adults and Renally Impaired Individuals

2020 . Hanke, Nina | Türk, Denise | Selzer, Dominik | Ishiguro, Naoki | Ebner, Thomas | Wiebe, Sabrina | Müller, Fabian | Stopfer, Peter | Nock, Valerie | Lehr, Thorsten