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Effect of Age, Sex, Renal Impairment and Hepatic Impairment on the Safety, Pharmacokinetics and Pharmacodynamics of Asundexian

2024 . Brase, Christine | Schmitz, Sebastian | Sommer, Katharina | Halabi, Atef | Kanefendt, Friederike

Development of a Weight-Band Dosing Approach for Vosoritide in Children with Achondroplasia Using a Population Pharmacokinetic Model

2024 . Qi, Yulan | Chan, Ming Liang | Mould, Diane R. | Larimore, Kevin | Fisheleva, Elena | Cherukuri, Anu | Day, Jonathan | Savarirayan, Ravi | Irving, Melita | Bacino, Carlos A. | Hoover-Fong, Julie | Ozono, Keiichi | Mohnike, Klaus | Wilcox, William R. | Bober, Michael B. | Henshaw, Joshua

Time Course of the Interaction Between Oral Short-Term Ritonavir Therapy with Three Factor Xa Inhibitors and the Activity of CYP2D6, CYP2C19, and CYP3A4 in Healthy Volunteers

2024 . Rohr, Brit S. | Krohmer, Evelyn | Foerster, Kathrin Isabelle | Burhenne, Jürgen | Schulz, Martin | Blank, Antje | Mikus, Gerd | Haefeli, Walter E.

Population Pharmacokinetics of Intravenous Paracetamol and Its Metabolites in Extreme Preterm Neonates in the Context of Patent Ductus Arteriosus Treatment

Towards Model-Informed Precision Dosing of Voriconazole: Challenging Published Voriconazole Nonlinear Mixed-Effects Models with Real-World Clinical Data

2023 . Kluwe, Franziska | Michelet, Robin | Huisinga, Wilhelm | Zeitlinger, Markus | Mikus, Gerd | Kloft, Charlotte

CYP3A and CYP2C19 Activity Determined by Microdosed Probe Drugs Accurately Predict Voriconazole Clearance in Healthy Adults

2023 . Muhareb, Amin | Blank, Antje | Meid, Andreas | Foerster, Kathrin Isabelle | Stoll, Felicitas | Burhenne, Jürgen | Haefeli, Walter E. | Mikus, Gerd

Quantification of the Time Course of CYP3A Inhibition, Activation, and Induction Using a Population Pharmacokinetic Model of Microdosed Midazolam Continuous Infusion

2022 . Nassar, Yomna M | Hohmann, Nicolas | Michelet, Robin | Gottwalt, Katharina | Meid, Andreas D. | Burhenne, Jürgen | Huisinga, Wilhelm | Haefeli, Walter E. | Mikus, Gerd | Kloft, Charlotte

Influence of CYP2D6 Phenotypes on the Pharmacokinetics of Aripiprazole and Dehydro-Aripiprazole Using a Physiologically Based Pharmacokinetic Approach

2021 . Kneller, Lisa Alina | Zubiaur, Pablo | Koller, Dora | Abad-Santos, Francisco | Hempel, Georg

Perpetrator Characteristics of Azole Antifungal Drugs on Three Oral Factor Xa Inhibitors Administered as a Microdosed Cocktail

2021 . Rohr, Brit Silja | Foerster, Kathrin Isabelle | Blank, Antje | Burhenne, Jürgen | Mahmoudi, Mazyar | Haefeli, Walter Emil | Mikus, Gerd

Comparative Plasma and Interstitial Tissue Fluid Pharmacokinetics of Meropenem Demonstrate the Need for Increasing Dose and Infusion Duration in Obese and Non-obese Patients

2021 . Busse, David | Simon, Philipp | Schmitt, Lisa | Petroff, David | Dorn, Christoph | Dietrich, Arne | Zeitlinger, Markus | Huisinga, Wilhelm | Michelet, Robin | Wrigge, Hermann | Kloft, Charlotte

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