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Striated muscle-specific base editing enables correction of mutations causing dilated cardiomyopathy

Context-specific effects of NOX4 inactivation in acute myeloid leukemia (AML)

2022 . Demircan, Muhammed Burak | Schnoeder, Tina M. | Mgbecheta, Peter C. | Schröder, Katrin | Böhmer, Frank-D. | Heidel, Florian

A Novel SCA3 Knock-in Mouse Model Mimics the Human SCA3 Disease Phenotype Including Neuropathological, Behavioral, and Transcriptional Abnormalities Especially in Oligodendrocytes

2021 . Haas, Eva | Incebacak, Rana D. | Hentrich, Thomas | Huridou, Chrisovalantou | Schmidt, Thorsten | Casadei, Nicolas | Maringer, Yacine | Bahl, Carola | Zimmermann, Frank | Mills, James D. | Aronica, Eleonora | Riess, Olaf | Schulze-Hentrich, Julia M. | Hübener-Schmid, Jeannette

Kinetics of poly(ADP-ribosyl)ation, but not PARP1 itself, determines the cell fate in response to DNA damage in vitro and in vivo