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In vivo CRISPR/Cas9-mediated screen reveals a critical function of TFDP1 and E2F4 transcription factors in hematopoiesis

2024 . Tran, Ngoc-Tung | Graf, Robin | Acevedo-Ochoa, Ernesto | Trombke, Janine | Weber, Timm | Sommermann, Thomas | Salomon, Claudia | Kühn, Ralf | Rajewsky, Klaus | Chu, Van Trung

miR-147b mediated suppression of DUSP8 promotes lung cancer progression

2024 . Turkowski, Kati | Herzberg, Frederik | Günther, Stefan | Weigert, Andreas | Haselbauer, Tamara | Fink, Ludger | Brunn, David | Grimminger, Friedrich | Seeger, Werner | Sültmann, Holger | Stiewe, Thorsten | Pullamsetti, Soni Savai | Savai, Rajkumar

Arginine methylation of caspase-8 controls life/death decisions in extrinsic apoptotic networks

2024 . Wohlfromm, Fabian | Ivanisenko, Nikita V. | Pietkiewicz, Sabine | König, Corinna | Seyrek, Kamil | Kähne, Thilo | Lavrik, Inna

Advancing rare disease treatment: EMA’s decade-long insights into engineered adoptive cell therapy for rare cancers and orphan designation

2024 . Kalland, Maria Elisabeth | Pose Boirazian, Tomas | Palomo Carrasco, Gloria Maria | Naumann-Winter, Frauke | Costa, Enrico | Matusevicius, Darius | Duarte, Dinah | Malikova, Eva | Vitezic, Dinko | Larsson, Kristina | Magrelli, Armando | Stoyanova-Beninska, Violeta | Mariz, Segundo

Proteomic profiling reveals ACSS2 facilitating metabolic support in acute myeloid leukemia

Selective degradation of mutant FMS-like tyrosine kinase-3 requires BIM-dependent depletion of heat shock proteins

2024 . Halilovic, Melisa | Abdelsalam, Mohamed | Zabkiewicz, Joanna | Lazenby, Michelle | Alvares, Caroline | Schmidt, Matthias | Brenner, Walburgis | Najafi, Sara | Oehme, Ina | Hieber, Christoph | Zeyn, Yanira | Bros, Matthias | Sippl, Wolfgang | Krämer, Oliver

Normalization of Snai1-mediated vessel dysfunction increases drug response in cancer

Glucocorticoid treatment influences prostate cancer cell growth and the tumor microenvironment via altered glucocorticoid receptor signaling in prostate fibroblasts

The RORɣ/SREBP2 pathway is a master regulator of cholesterol metabolism and serves as potential therapeutic target in t(4;11) leukemia

2023 . Erkner, Estelle | Hentrich, Thomas | Schairer, Rebekka | Fitzel, Rahel | Secker-Grob, Kathy-Ann | Jeong, Johan | Keppeler, Hildegard | Korkmaz, Fulya | Schulze-Hentrich, Julia M. | Lengerke, Claudia | Schneidawind, Dominik | Schneidawind, Corina