Fachrepositorium Lebenswissenschaften

7 Treffer

Suche

Publisso-Menue

PBTK modeling of the pyrrolizidine alkaloid retrorsine to predict liver toxicity in mouse and rat

2023 . Lehmann, Anja | Geburek, Ina | These, Anja | Hessel-Pras, Stefanie | Hengstler, Jan | Albrecht, Wiebke | Mielke, Hans | Müller-Graf, Christine | Yang, Xiaojing | Kloft, Charlotte | Hethey, Christoph

Towards Model-Informed Precision Dosing of Voriconazole: Challenging Published Voriconazole Nonlinear Mixed-Effects Models with Real-World Clinical Data

2023 . Kluwe, Franziska | Michelet, Robin | Huisinga, Wilhelm | Zeitlinger, Markus | Mikus, Gerd | Kloft, Charlotte

Tigecycline Soft Tissue Penetration in Obese and Non-obese Surgical Patients Determined by Using In Vivo Microdialysis

2022 . Dorn, Christoph | Petroff, David | Kratzer, Alexander | Kees, Frieder | Kloft, Charlotte | Zeitlinger, Markus | Wrigge, Hermann | Simon, Philipp

Quantification of the Time Course of CYP3A Inhibition, Activation, and Induction Using a Population Pharmacokinetic Model of Microdosed Midazolam Continuous Infusion

2022 . Nassar, Yomna M | Hohmann, Nicolas | Michelet, Robin | Gottwalt, Katharina | Meid, Andreas D. | Burhenne, Jürgen | Huisinga, Wilhelm | Haefeli, Walter E. | Mikus, Gerd | Kloft, Charlotte

Which Analysis Approach Is Adequate to Leverage Clinical Microdialysis Data? A Quantitative Comparison to Investigate Exposure and Response Exemplified by Levofloxacin

2021 . Busse, David | Schaeftlein, André | Solms, Alexander | Ilia, Luis | Michelet, Robin | Zeitlinger, Markus | Huisinga, Wilhelm | Kloft, Charlotte

CYP2D6 phenotype explains reported yohimbine concentrations in four severe acute intoxications

2021 . Mc Laughlin, Anna M. | Michelet, Robin | Weinelt, Ferdinand | Kloft, Charlotte | Mikus, Gerd

Comparative Plasma and Interstitial Tissue Fluid Pharmacokinetics of Meropenem Demonstrate the Need for Increasing Dose and Infusion Duration in Obese and Non-obese Patients

2021 . Busse, David | Simon, Philipp | Schmitt, Lisa | Petroff, David | Dorn, Christoph | Dietrich, Arne | Zeitlinger, Markus | Huisinga, Wilhelm | Michelet, Robin | Wrigge, Hermann | Kloft, Charlotte