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Population pharmacokinetics of TLD-1, a novel liposomal doxorubicin, in a phase I trial

A quantitative modeling framework to understand the physiology of the hypothalamic-pituitary-adrenal axis and interaction with cortisol replacement therapy

2024 . Bindellini, Davide | Michelet, Robin | Aulin, Linda | Melin, Johanna | Neumann, Uta | Blankenstein, Oliver | Huisinga, Wilhelm | Whitaker, Martin | Ross, Richard | Kloft, Charlotte

PBTK model-based analysis of CYP3A4 induction and the toxicokinetics of the pyrrolizidine alkaloid retrorsine in man

2024 . Lehmann, Anja | Geburek, Ina | Hessel-Pras, Stefanie | Enge, Anne-Margarethe | Mielke, Hans | Müller-Graf, Christine | Kloft, Charlotte | Hethey, Christoph

PBTK modeling of the pyrrolizidine alkaloid retrorsine to predict liver toxicity in mouse and rat

2023 . Lehmann, Anja | Geburek, Ina | These, Anja | Hessel-Pras, Stefanie | Hengstler, Jan | Albrecht, Wiebke | Mielke, Hans | Müller-Graf, Christine | Yang, Xiaojing | Kloft, Charlotte | Hethey, Christoph

Towards Model-Informed Precision Dosing of Voriconazole: Challenging Published Voriconazole Nonlinear Mixed-Effects Models with Real-World Clinical Data

2023 . Kluwe, Franziska | Michelet, Robin | Huisinga, Wilhelm | Zeitlinger, Markus | Mikus, Gerd | Kloft, Charlotte

Impact of Key Components of Intensified Ceftaroline Dosing on Pharmacokinetic/Pharmacodynamic Target Attainment

2023 . Minichmayr, Iris | Wicha, Sebastian G. | Matzneller, Peter | Kloft, Charlotte | Zeitlinger, Markus

Quantification of the Time Course of CYP3A Inhibition, Activation, and Induction Using a Population Pharmacokinetic Model of Microdosed Midazolam Continuous Infusion

2022 . Nassar, Yomna M | Hohmann, Nicolas | Michelet, Robin | Gottwalt, Katharina | Meid, Andreas D. | Burhenne, Jürgen | Huisinga, Wilhelm | Haefeli, Walter E. | Mikus, Gerd | Kloft, Charlotte

Tigecycline Soft Tissue Penetration in Obese and Non-obese Surgical Patients Determined by Using In Vivo Microdialysis

2022 . Dorn, Christoph | Petroff, David | Kratzer, Alexander | Kees, Frieder | Kloft, Charlotte | Zeitlinger, Markus | Wrigge, Hermann | Simon, Philipp

Which Analysis Approach Is Adequate to Leverage Clinical Microdialysis Data? A Quantitative Comparison to Investigate Exposure and Response Exemplified by Levofloxacin

2021 . Busse, David | Schaeftlein, André | Solms, Alexander | Ilia, Luis | Michelet, Robin | Zeitlinger, Markus | Huisinga, Wilhelm | Kloft, Charlotte

CYP2D6 phenotype explains reported yohimbine concentrations in four severe acute intoxications

2021 . Mc Laughlin, Anna M. | Michelet, Robin | Weinelt, Ferdinand | Kloft, Charlotte | Mikus, Gerd

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