1000 Titel
  • 3,5-Diiodo-L-Thyronine (3,5-T2) Exerts Thyromimetic Effects on Hypothalamus-Pituitary-Thyroid Axis, Body Composition, and Energy Metabolism in Male Diet-Induced Obese Mice
1000 Autor/in
  1. Jonas, Wenke |
  2. Lietzow, Julika |
  3. Wohlgemuth, Franziska |
  4. Hoefig, Carolin S. |
  5. Schweizer, Ulrich |
  6. Köhrle, Josef |
  7. Schürmann, Annette |
  8. Wiedmer, Petra |
1000 Erscheinungsjahr 2015
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2015-01-01
1000 Erschienen in
1000 Quellenangabe
  • 156 (1): 389-399
1000 FRL-Sammlung
1000 Verlagsversion
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272399/ |
  • https://doi.org/10.1210/en.2014-1604 |
1000 Ergänzendes Material
  • https://academic.oup.com/endo/article-lookup/doi/10.1210/en.2014-1604#supplementary-data |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Effective and safe antiobesity drugs are still needed in face of the obesity pandemic worldwide. Recent interventions in rodents revealed 3,5-diiodo-L-thyronine (3,5-T2) as a metabolically active iodothyronine affecting energy and lipid metabolism without thyromimetic side effects typically associated with T3 administration. Accordingly, 3,5-T2 has been proposed as a potential hypolipidemic agent for treatment of obesity and hepatic steatosis. In contrast to other observations, our experiments revealed dose-dependent thyromimetic effects of 3,5-T2 akin to those of T3 in diet-induced obese male C57BL/6J mice. 3,5-T2 treatment exerted a negative feedback regulation on the hypothalamus-pituitary-thyroid axis, similar to T3. This is demonstrated by decreased expression of genes responsive to thyroid hormones (TH) in pituitary resulting in a suppressed thyroid function with lower T4 and T3 concentrations in serum and liver of 3,5-T2-treated mice. Analyses of hepatic TH target genes involved in lipid metabolism revealed T3-like changes in gene expression and increased type I-deiodinase activity after application of 3,5-T2 (2.5 μg/g body weight). Reduced hepatic triglyceride and serum cholesterol concentrations reflected enhanced lipid metabolism. Desired increased metabolic rate and reduction of different fat depots were, however, compromised by increased food intake preventing significant body weight loss. Moreover, enlarged heart weights indicate potential cardiac side effects of 3,5-T2 beyond hepatic thyromimetic actions. Altogether, the observed thyromimetic effects of 3,5-T2 in several mouse TH target tissues raise concern about indiscriminate administration of 3,5-T2 as powerful natural hormone for the treatment of hyperlipidemia and pandemic obesity.
1000 Sacherschließung
lokal fatty liver
lokal iodide peroxidase
lokal pandemic
lokal pituitary gland
lokal mice
lokal hormone
lokal feedback
lokal body composition
lokal mice, inbred c57bl
lokal weight reduction
lokal mice, obese
lokal diet
lokal rodentia
lokal energy metabolism
lokal obesity
lokal genes
lokal liver
lokal metabolic rate
lokal antilipemic agents
lokal triglycerides
lokal eating
lokal heart
lokal candidate disease gene
lokal thyroid
lokal anti-obesity agents
lokal thyroid function tests
lokal thyroid hormones
lokal serum cholesterol measurement
lokal fat metabolism
lokal gene expression
lokal hypothalamus
1000 Fachgruppe
  1. Medizin |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/Sm9uYXMsIFdlbmtl|https://frl.publisso.de/adhoc/creator/TGlldHpvdywgSnVsaWth|https://frl.publisso.de/adhoc/creator/V29obGdlbXV0aCwgRnJhbnppc2th|https://frl.publisso.de/adhoc/creator/SG9lZmlnLCBDYXJvbGluIFMu|https://frl.publisso.de/adhoc/creator/U2Nod2VpemVyLCBVbHJpY2g=|https://frl.publisso.de/adhoc/creator/S8O2aHJsZSwgSm9zZWY=|https://frl.publisso.de/adhoc/creator/U2Now7xybWFubiwgQW5uZXR0ZQ==|http://orcid.org/0000-0001-7284-7823
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1000 Erstellt am 2017-05-05T10:46:20.956+0200
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1000 Zuletzt bearbeitet Thu Jan 30 15:22:02 CET 2020
1000 Objekt bearb. Wed Apr 11 10:31:36 CEST 2018
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1000 Oai Id
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