1000 Titel
  • 3,5-Diiodo-L-Thyronine (3,5-T2) Exerts Thyromimetic Effects on Hypothalamus-Pituitary-Thyroid Axis, Body Composition, and Energy Metabolism in Male Diet-Induced Obese Mice
1000 Autor/in
  1. Jonas, Wenke |
  2. Lietzow, Julika |
  3. Wohlgemuth, Franziska |
  4. Hoefig, Carolin S. |
  5. Schweizer, Ulrich |
  6. Köhrle, Josef |
  7. Schürmann, Annette |
  8. Wiedmer, Petra |
1000 Erscheinungsjahr 2015
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2015-01-01
1000 Erschienen in
1000 Quellenangabe
  • 156 (1): 389-399
1000 FRL-Sammlung
1000 Verlagsversion
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4272399/ |
  • https://doi.org/10.1210/en.2014-1604 |
1000 Ergänzendes Material
  • https://academic.oup.com/endo/article-lookup/doi/10.1210/en.2014-1604#supplementary-data |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Effective and safe antiobesity drugs are still needed in face of the obesity pandemic worldwide. Recent interventions in rodents revealed 3,5-diiodo-L-thyronine (3,5-T2) as a metabolically active iodothyronine affecting energy and lipid metabolism without thyromimetic side effects typically associated with T3 administration. Accordingly, 3,5-T2 has been proposed as a potential hypolipidemic agent for treatment of obesity and hepatic steatosis. In contrast to other observations, our experiments revealed dose-dependent thyromimetic effects of 3,5-T2 akin to those of T3 in diet-induced obese male C57BL/6J mice. 3,5-T2 treatment exerted a negative feedback regulation on the hypothalamus-pituitary-thyroid axis, similar to T3. This is demonstrated by decreased expression of genes responsive to thyroid hormones (TH) in pituitary resulting in a suppressed thyroid function with lower T4 and T3 concentrations in serum and liver of 3,5-T2-treated mice. Analyses of hepatic TH target genes involved in lipid metabolism revealed T3-like changes in gene expression and increased type I-deiodinase activity after application of 3,5-T2 (2.5 μg/g body weight). Reduced hepatic triglyceride and serum cholesterol concentrations reflected enhanced lipid metabolism. Desired increased metabolic rate and reduction of different fat depots were, however, compromised by increased food intake preventing significant body weight loss. Moreover, enlarged heart weights indicate potential cardiac side effects of 3,5-T2 beyond hepatic thyromimetic actions. Altogether, the observed thyromimetic effects of 3,5-T2 in several mouse TH target tissues raise concern about indiscriminate administration of 3,5-T2 as powerful natural hormone for the treatment of hyperlipidemia and pandemic obesity.
1000 Sacherschließung
lokal hormone
lokal feedback
lokal diet
lokal energy metabolism
lokal gene expression
lokal genes
lokal obesity
lokal liver
lokal antilipemic agents
lokal pandemic
lokal fatty liver
lokal candidate disease gene
lokal thyroid
lokal eating
lokal thyroid function tests
lokal fat metabolism
lokal anti-obesity agents
lokal body composition
lokal metabolic rate
lokal serum cholesterol measurement
lokal rodentia
lokal weight reduction
lokal triglycerides
lokal mice, obese
lokal heart
lokal iodide peroxidase
lokal mice, inbred c57bl
lokal mice
lokal hypothalamus
lokal pituitary gland
lokal thyroid hormones
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/Sm9uYXMsIFdlbmtl|https://frl.publisso.de/adhoc/creator/TGlldHpvdywgSnVsaWth|https://frl.publisso.de/adhoc/creator/V29obGdlbXV0aCwgRnJhbnppc2th|https://frl.publisso.de/adhoc/creator/SG9lZmlnLCBDYXJvbGluIFMu|https://frl.publisso.de/adhoc/creator/U2Nod2VpemVyLCBVbHJpY2g=|https://frl.publisso.de/adhoc/creator/S8O2aHJsZSwgSm9zZWY=|https://frl.publisso.de/adhoc/creator/U2Now7xybWFubiwgQW5uZXR0ZQ==|http://orcid.org/0000-0001-7284-7823
1000 Label
1000 Fördernummer
  1. -
1000 Förderprogramm
  1. -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6402284.rdf
1000 Erstellt am 2017-05-05T10:46:20.956+0200
1000 Erstellt von 25
1000 beschreibt frl:6402284
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Fri Oct 14 17:47:05 CEST 2022
1000 Objekt bearb. Fri Oct 14 17:47:05 CEST 2022
1000 Vgl. frl:6402284
1000 Oai Id
  1. oai:frl.publisso.de:frl:6402284 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source