WeightNameValue
1000 Titel
  • Trafficking and Proteolytic Processing of APP
1000 Autor/in
  1. Haass, Christian |
  2. Kaether, Christoph |
  3. Thinakaran, Gopal |
  4. Sisodia, Sangram |
1000 Erscheinungsjahr 2012
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2012-05
1000 Erschienen in
1000 Quellenangabe
  • 2(5): a006270
1000 FRL-Sammlung
1000 Verlagsversion
  • http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331683/ |
  • http://doi.org/10.1101/cshperspect.a006270 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Accumulations of insoluble deposits of amyloid β-peptide are major pathological hallmarks of Alzheimer disease. Amyloid β-peptide is derived by sequential proteolytic processing from a large type I trans-membrane protein, the β-amyloid precursor protein. The proteolytic enzymes involved in its processing are named secretases. β- and γ-secretase liberate by sequential cleavage the neurotoxic amyloid β-peptide, whereas α-secretase prevents its generation by cleaving within the middle of the amyloid domain. In this chapter we describe the cell biological and biochemical characteristics of the three secretase activities involved in the proteolytic processing of the precursor protein. In addition we outline how the precursor protein maturates and traffics through the secretory pathway to reach the subcellular locations where the individual secretases are preferentially active. Furthermore, we illuminate how neuronal activity and mutations which cause familial Alzheimer disease affect amyloid β-peptide generation and therefore disease onset and progression.
1000 Fachgruppe
  1. Medizin |
  2. Gesundheitswesen |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/SGFhc3MsIENocmlzdGlhbg==|https://frl.publisso.de/adhoc/creator/S2FldGhlciwgQ2hyaXN0b3Bo|https://frl.publisso.de/adhoc/creator/VGhpbmFrYXJhbiwgR29wYWw=|https://frl.publisso.de/adhoc/creator/U2lzb2RpYSwgU2FuZ3JhbQ==
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6402412.rdf
1000 Erstellt am 2017-05-11T13:30:08.862+0200
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1000 Bearbeitet von 218
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1000 Vgl. frl:6402412
1000 Oai Id
  1. oai:frl.publisso.de:frl:6402412 |
1000 Sichtbarkeit Metadaten public
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