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1000 Titel
  • Regional distribution of body fat in relation to DNA methylation within the LPL, ADIPOQ and PPARγ promoters in subcutaneous adipose tissue
1000 Autor/in
  1. Drogan, D |
  2. Boeing, H |
  3. Janke, J |
  4. Schmitt, B |
  5. Zhou, Y |
  6. Walter, J |
  7. Tierling, S |
  8. Pischon, Tobias |
1000 Erscheinungsjahr 2015
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2015-07-06
1000 Erschienen in
1000 Quellenangabe
  • 5: e168
1000 FRL-Sammlung
1000 Lizenz
1000 Verlagsversion
  • http://doi.org/10.1038/nutd.2015.19 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4521174/ |
1000 Ergänzendes Material
  • https://www.nature.com/nutd/journal/v5/n7/suppinfo/nutd201519s1.html?url=/nutd/journal/v5/n7/full/nutd201519a.html |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Obesity may be related to differential DNA methylation and thus to differential expression of key genes in adipose tissue metabolism, such as LPL, ADIPOQ and PPARγ. Using subcutaneous adipose tissue (SAT) from 59 individuals of the European Prospective Investigation into Cancer and Nutrition–Potsdam study, we performed quantitative DNA methylation analysis within the promoters of LPL (LPL-CG1 and -CG2), ADIPOQ (ADIPOQ-CG1 and-CG2) and PPARγ (PPARγ-CG1). We then studied DNA methylation in relation to SAT gene expression, body composition measured using whole-body magnetic resonance imaging, body mass index (BMI), waist circumference (WC) and long-term changes in BMI and WC. For LPL-CG1 and LPL-CG2, higher methylation levels were associated with lower LPL expression, but with higher past WC gain. LPL-CG1 was also positively associated with BMI, WC, and visceral and subcutaneous fat mass. ADIPOQ-CG1 or -CG2 methylation exhibited no association with ADIPOQ expression or with anthropometric parameters. PPARγ-CG1 methylation was significantly higher in individuals with higher visceral fat mass. Among the investigated sites, LPL-CG1 methylation showed the strongest association with gene expression and regional body fat distribution, thereby possibly linking the degree of obesity with major metabolic processes in SAT.
1000 Fachgruppe
  1. Ernährungswissenschaften |
  2. Biologie |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/RHJvZ2FuLCBE|https://frl.publisso.de/adhoc/creator/Qm9laW5nLCBI|https://frl.publisso.de/adhoc/creator/SmFua2UsIEo=|https://frl.publisso.de/adhoc/creator/U2NobWl0dCwgQg==|https://frl.publisso.de/adhoc/creator/WmhvdSwgWQ==|https://frl.publisso.de/adhoc/creator/V2FsdGVyLCBK|https://frl.publisso.de/adhoc/creator/VGllcmxpbmcsIFM=|http://orcid.org/0000-0003-1568-767X
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1000 @id frl:6402618.rdf
1000 Erstellt am 2017-05-26T13:30:21.526+0200
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1000 Vgl. frl:6402618
1000 Oai Id
  1. oai:frl.publisso.de:frl:6402618 |
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