Circulating prolactin and in situ breast cancer risk in the European EPIC cohort: a case-control study

  1. Tikk, Kaja
  2. Sookthai, Disorn
  3. Fortner, Renée T
  4. Johnson, Theron
  5. Rinaldi, Sabina
  6. Romieu, Isabelle
  7. Tjønneland, Anne
  8. Olsen, Anja
  9. Overvad, Kim
  10. Clavel-Chapelon, Françoise
  11. Baglietto, Laura
  12. Boeing, Heiner
  13. Trichopoulou, Antonia
  14. Lagiou, Pagona
  15. Trichopoulos, Dimitrios
  16. Masala, Giovanna
  17. Krogh, Vittorio
  18. Tumino, Rosario
  19. Ricceri, Fulvio
  20. Mattiello, Amalia
  21. Agudo, Antonio
  22. Menéndez, Virginia
  23. Sánchez, María-José
  24. Amiano, Pilar
  25. Chirlaque, Maria-Dolores
  26. Barricarte, Aurelio
  27. Bueno-de-Mesquita, H Bas
  28. Monninkhof, Evelyn M
  29. Onland-Moret, N Charlotte
  30. Andresson, Anne
  31. Sund, Malin
  32. Weiderpass, Elisabete
  33. Khaw, Kay-Tee
  34. Key, Timothy J
  35. Travis, Ruth C
  36. Merritt, Melissa A
  37. Riboli, Elio
  38. Dossus, Laure
  39. Kaaks, Rudolf

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WeightNameValue
1000 Titel
  • Circulating prolactin and in situ breast cancer risk in the European EPIC cohort: a case-control study
1000 Autor/in
  1. Tikk, Kaja |
  2. Sookthai, Disorn |
  3. Fortner, Renée T |
  4. Johnson, Theron |
  5. Rinaldi, Sabina |
  6. Romieu, Isabelle |
  7. Tjønneland, Anne |
  8. Olsen, Anja |
  9. Overvad, Kim |
  10. Clavel-Chapelon, Françoise |
  11. Baglietto, Laura |
  12. Boeing, Heiner |
  13. Trichopoulou, Antonia |
  14. Lagiou, Pagona |
  15. Trichopoulos, Dimitrios |
  16. Masala, Giovanna |
  17. Krogh, Vittorio |
  18. Tumino, Rosario |
  19. Ricceri, Fulvio |
  20. Mattiello, Amalia |
  21. Agudo, Antonio |
  22. Menéndez, Virginia |
  23. Sánchez, María-José |
  24. Amiano, Pilar |
  25. Chirlaque, Maria-Dolores |
  26. Barricarte, Aurelio |
  27. Bueno-de-Mesquita, H Bas |
  28. Monninkhof, Evelyn M |
  29. Onland-Moret, N Charlotte |
  30. Andresson, Anne |
  31. Sund, Malin |
  32. Weiderpass, Elisabete |
  33. Khaw, Kay-Tee |
  34. Key, Timothy J |
  35. Travis, Ruth C |
  36. Merritt, Melissa A |
  37. Riboli, Elio |
  38. Dossus, Laure |
  39. Kaaks, Rudolf |
1000 Erscheinungsjahr 2015
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2015-03-31
1000 Erschienen in
1000 Quellenangabe
  • 17(1):49
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2015
1000 Lizenz
1000 Verlagsversion
  • https://dx.doi.org/10.1186/s13058-015-0563-6 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413538/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • INTRODUCTION: The relationship between circulating prolactin and invasive breast cancer has been investigated previously, but the association between prolactin levels and in situ breast cancer risk has received less attention. METHODS: We analysed the relationship between pre-diagnostic prolactin levels and the risk of in situ breast cancer overall, and by menopausal status and use of postmenopausal hormone therapy (HT) at blood donation. Conditional logistic regression was used to assess this association in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, including 307 in situ breast cancer cases and their matched control subjects. RESULTS: We found a significant positive association between higher circulating prolactin levels and risk of in situ breast cancer among all women [pre-and postmenopausal combined, ORlog2=1.35 (95% CI 1.04-1.76), Ptrend=0.03]. No statistically significant heterogeneity was found between prolactin levels and in situ cancer risk by menopausal status (Phet=0.98) or baseline HT use (Phet=0.20), although the observed association was more pronounced among postmenopausal women using HT compared to non-users (Ptrend=0.06 vs Ptrend=0.35). In subgroup analyses, the observed positive association was strongest in women diagnosed with in situ breast tumors<4 years compared to ≥4 years after blood donation (Ptrend=0.01 vs Ptrend=0.63; Phet=0.04) and among nulliparous women compared to parous women (Ptrend=0.03 vs Ptrend=0.15; Phet=0.07). CONCLUSIONS: Our data extends prior research linking prolactin and invasive breast cancer to the outcome of in situ breast tumours and shows that higher circulating prolactin is associated with increased risk of in situ breast cancer.
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