Download
journal.pone.0088060.PDF 2,69MB
WeightNameValue
1000 Titel
  • Locus Characterization and Gene Expression of Bovine FNDC5: Is the Myokine Irisin Relevant in Cattle?
1000 Autor/in
  1. Komolka, Katrin |
  2. Albrecht, Elke |
  3. Schering, Lisa |
  4. Brenmoehl, Julia |
  5. Hoeflich, Andreas |
  6. Maak, Steffen |
1000 Erscheinungsjahr 2014
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2014-01-31
1000 Erschienen in
1000 Quellenangabe
  • 9(1): e88060
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2014
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1371/journal.pone.0088060 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909329/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The transmembrane protein FNDC5 was recently characterized as precursor of an exercise induced myokine named irisin. Previous studies found a relationship between circulating irisin levels and muscle mass in humans. Consequently, we tested the hypothesis whether FNDC5/irisin is involved in the modulation of body composition in cattle. Since information on the bovine FNDC5 locus was scarce, we characterized the gene experimentally as prerequisite for these investigations. We provide here a revised and extended gene model for bovine FNDC5. Although similarly organized like the human and murine loci, a higher variability was observed at transcript level in the bovine locus. FNDC5 mRNA was abundant in bovine skeletal muscle and was detected at lower levels in adipose tissue and liver. There were no expression differences between two groups of bulls highly different in muscularity and adiposity. Full-length FNDC5 protein (25 kDa) was present in bovine skeletal muscle independent of muscularity. Neither FNDC5 nor its putatively secreted peptide irisin were found in circulation of bulls. In contrast, we demonstrated that FNDC5 (25 kDa) and irisin (12 kDa) were present in murine skeletal muscle and that irisin was circulating in murine serum. This indicates fundamental differences in the regulation of FNDC5 and irisin between rodents and cattle.
1000 Sacherschließung
lokal Messenger RNA
lokal Skeletal muscles
lokal Cattle
lokal Bovines
lokal Genetic loci
lokal Gene expression
lokal Muscle proteins
lokal Mammalian genomics
1000 Fachgruppe
  1. Medizin |
  2. Biologie |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/S29tb2xrYSwgS2F0cmluIA==|http://orcid.org/0000-0001-5974-1514|https://frl.publisso.de/adhoc/creator/U2NoZXJpbmcsIExpc2Eg|https://frl.publisso.de/adhoc/creator/QnJlbm1vZWhsLCBKdWxpYQ==|http://orcid.org/0000-0003-2018-2836|http://orcid.org/0000-0003-2681-1496
1000 Label
1000 Förderer
  1. Leibniz Association |
1000 Fördernummer
  1. SAW-2013-FBN-3
1000 Förderprogramm
  1. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Leibniz Association |
    1000 Förderprogramm -
    1000 Fördernummer SAW-2013-FBN-3
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6402653.rdf
1000 Erstellt am 2017-05-31T10:54:44.648+0200
1000 Erstellt von 23
1000 beschreibt frl:6402653
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Thu Jan 30 22:52:12 CET 2020
1000 Objekt bearb. Thu Nov 15 12:20:05 CET 2018
1000 Vgl. frl:6402653
1000 Oai Id
  1. oai:frl.publisso.de:frl:6402653 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source