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1000 Titel
  • Large Differences in Aging Phenotype between Strains of the Short-Lived Annual Fish Nothobranchius furzeri
1000 Autor/in
  1. Terzibasi Tozzini, Eva |
  2. Valenzano, Dario Riccardo |
  3. Benedetti, Mauro |
  4. Roncaglia, Paola |
  5. Cattaneo, Antonino |
  6. Domenici, Luciano |
  7. Cellerino, Alessandro |
1000 Erscheinungsjahr 2008
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2008-12-04
1000 Erschienen in
1000 Quellenangabe
  • 3(12): e3866
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2008
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1371/journal.pone.0003866 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2585814/ |
1000 Ergänzendes Material
  • http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0003866#s5 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: A laboratory inbred strain of the annual fish Nothobranchius furzeri shows exceptionally short life expectancy and accelerated expression of age markers. In this study, we analyze new wild-derived lines of this short-lived species. METHODOLOGY/PRINCIPLE FINDINGS: We characterized captive survival and age-related traits in F1 and F2 offspring of wild-caught N. furzeri. Wild-derived N. furzeri lines showed expression of lipofuscin and neurodegeneration at age 21 weeks. Median lifespan in the laboratory varied from to 20 to 23 weeks and maximum lifespan from 25 to 32 weeks. These data demonstrate that rapid age-dependent decline and short lifespan are natural characteristics of this species. The N. furzeri distribution range overlaps with gradients in altitude and aridity. Fish from more arid habitats are expected to experience a shorter survival window in the wild. We tested whether captive lines stemming from semi-arid and sub-humid habitats differ in longevity and expression of age-related traits. We detected a clear difference in age-dependent cognitive decline and a slight difference in lifespan (16% for median, 15% for maximum lifespan) between these lines. Finally, we observed shorter lifespan and accelerated expression of age-related markers in the inbred laboratory strain compared to these wild-derived lines. CONCLUSIONS/SIGNIFICANCE: Owing to large differences in aging phenotypes in different lines, N. furzeri could represent a model system for studying the genetic control of life-history traits in natural populations.
1000 Sacherschließung
lokal Hindbrain
lokal Superior colliculus
lokal Fishes
lokal Phenotypes
lokal Habitats
lokal Cerebrum
lokal Cognitive impairment
lokal Inbred strains
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. http://orcid.org/0000-0003-3317-1538|https://frl.publisso.de/adhoc/creator/VmFsZW56YW5vLCBEYXJpbyBSaWNjYXJkbw==|https://frl.publisso.de/adhoc/creator/QmVuZWRldHRpLCBNYXVybw==|https://frl.publisso.de/adhoc/creator/Um9uY2FnbGlhLCBQYW9sYQ==|https://frl.publisso.de/adhoc/creator/Q2F0dGFuZW8sIEFudG9uaW5v|https://frl.publisso.de/adhoc/creator/RG9tZW5pY2ksIEx1Y2lhbm8=|http://orcid.org/0000-0003-3834-0097
1000 Label
1000 Förderer
  1. LayLineGenomics S.p.A |
  2. Scuola Normale Superiore |
  3. Leibniz Gemeinschaft |
1000 Fördernummer
  1. -
  2. -
  3. -
1000 Förderprogramm
  1. -
  2. -
  3. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer LayLineGenomics S.p.A |
    1000 Förderprogramm -
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer Scuola Normale Superiore |
    1000 Förderprogramm -
    1000 Fördernummer -
  3. 1000 joinedFunding-child
    1000 Förderer Leibniz Gemeinschaft |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
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1000 @id frl:6402737.rdf
1000 Erstellt am 2017-06-02T09:10:07.216+0200
1000 Erstellt von 21
1000 beschreibt frl:6402737
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet 2020-11-25T16:09:42.707+0100
1000 Objekt bearb. Wed Nov 25 16:09:42 CET 2020
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1000 Oai Id
  1. oai:frl.publisso.de:frl:6402737 |
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