WeightNameValue
1000 Titel
  • Quantitative Trait Loci Affecting Body Weight and Fatness From a Mouse Line Selected for Extreme High Growth
1000 Autor/in
  1. Brockmann, Gudrun A. |
  2. Haley, Chris S. |
  3. Renne, Ulla |
  4. Knott, Sara A. |
  5. Schwerin, Manfred |
1000 Erscheinungsjahr 1998
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 1998-09-01
1000 Erschienen in
1000 Quellenangabe
  • 150(1): 369-381
1000 FRL-Sammlung
1000 Verlagsversion
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1460298/ |
  • http://www.genetics.org/content/150/1/369.short |
1000 Ergänzendes Material
  • http://www.genetics.org/content/150/1/369.figures-only |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Quantitative trait loci (QTL) influencing body weight were mapped by linkage analysis in crosses between a high body weight selected line (DU6) and a control line (DUKs). The two mouse lines differ in body weight by 106% and in abdominal fat weight by 100% at 42 days. They were generated from the same base population and maintained as outbred colonies. Determination of line-specific allele frequencies at microsatellite markers spanning the genome indicated significant changes between the lines on 15 autosomes and the X chromosome. To confirm these effects, a QTL analysis was performed using structured F2 pedigrees derived from crosses of a single male from DU6 with a female from DUKs. QTL significant at the genome-wide level were mapped for body weight on chromosome 11; for abdominal fat weight on chromosomes 4, 11, and 13; for abdominal fat percentage on chromosomes 3 and 4; and for the weights of liver on chromosomes 4 and 11, of kidney on chromosomes 2 and 9, and of spleen on chromosome 11. The strong effect on body weight of the QTL on chromosome 11 was confirmed in three independent pedigrees. The effect was additive and independent of sex, accounting for 21–35% of the phenotypic variance of body weight within the corresponding F2 populations. The test for multiple QTL onchromosome 11 with combined data from all pedigrees indicated the segregation of two loci separated by 36 cM influencing body weight.
1000 Fachgruppe
  1. Gesundheitswesen |
  2. Ernährungswissenschaften |
  3. Biologie |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/QnJvY2ttYW5uLCBHdWRydW4gQS4=|https://frl.publisso.de/adhoc/creator/SGFsZXksIENocmlzIFMu|https://frl.publisso.de/adhoc/creator/UmVubmUsIFVsbGE=|https://frl.publisso.de/adhoc/creator/S25vdHQsIFNhcmEgQS4=|https://frl.publisso.de/adhoc/creator/U2Nod2VyaW4sIE1hbmZyZWQ=
1000 Förderer
  1. German Research Foundation |
  2. H. Wilhelm Schaumann Stiftung |
  3. Biotechnology and Biological Sciences Research Council (BBSRC), Ministry of Agriculture, Fisheries and Food (MAFF), U.K. |
  4. European Community (EC) |
  5. Royal Society |
1000 Fördernummer
  1. BR 1285/1-2; BR 1285/4-1
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1000 Förderprogramm
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1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer German Research Foundation |
    1000 Förderprogramm -
    1000 Fördernummer BR 1285/1-2; BR 1285/4-1
  2. 1000 joinedFunding-child
    1000 Förderer H. Wilhelm Schaumann Stiftung |
    1000 Förderprogramm -
    1000 Fördernummer -
  3. 1000 joinedFunding-child
    1000 Förderer Biotechnology and Biological Sciences Research Council (BBSRC), Ministry of Agriculture, Fisheries and Food (MAFF), U.K. |
    1000 Förderprogramm -
    1000 Fördernummer -
  4. 1000 joinedFunding-child
    1000 Förderer European Community (EC) |
    1000 Förderprogramm -
    1000 Fördernummer -
  5. 1000 joinedFunding-child
    1000 Förderer Royal Society |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6402851.rdf
1000 Erstellt am 2017-06-06T14:24:20.461+0200
1000 Erstellt von 25
1000 beschreibt frl:6402851
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Mon Jun 18 12:24:14 CEST 2018
1000 Objekt bearb. Mon Jun 18 12:24:14 CEST 2018
1000 Vgl. frl:6402851
1000 Oai Id
  1. oai:frl.publisso.de:frl:6402851 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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