v10p0327.pdf 1,88MB
1000 Titel
  • Discovery of Candidate Genes for Muscle Traits Based on GWAS Supported by eQTL-analysis
1000 Autor/in
  1. Ponsuksili, Siriluck |
  2. Murani, Eduard |
  3. Trakooljul, Nares |
  4. Schwerin, Manfred |
  5. Wimmers, Klaus |
1000 Erscheinungsjahr 2014
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2014-03-10
1000 Erschienen in
1000 Quellenangabe
  • 10(3): 327-337
1000 FRL-Sammlung
1000 Lizenz
1000 Verlagsversion
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  • |
1000 Ergänzendes Material
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1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Biochemical and biophysical processes that take place in muscle under relaxed and stressed conditions depend on the abundance and activity of gene products of metabolic and structural pathways. In livestock at post-mortem, these muscle properties determine aspects of meat quality and are measurable. The conversion of muscle to meat mimics pathological processes associated with muscle ischemia, injury or damage in humans and it is an economic factor in pork production. Linkage, association, and expression analyses independently contributed to the identification of trait-associated molecular pathways and genes. We aim at providing multiple evidences for the role of specific genes in meat quality by integrating a genome-wide association study (GWAS) for meat quality traits and the detection of eQTL based on trait-correlated expressed genes and trait-associated markers. The GWAS revealed 51 and 200 SNPs significantly associated with meat quality in a crossbred Pietrain×(German Landrace×Large White) (Pi×(GL×LW)) and a purebred German Landrace (GL) population, respectively. Most significant SNPs in Pi×(GL×LW) were located on chromosomes (SSC) 4 and 6. The data of 47,836 eQTLs at a significance level of p<10-5 were used to scale down the number candidate genes located in these regions. These SNPs on SSC4 showed association with expression levels of ZNF704, IMPA1, and OXSR1; SSC6 SNPs were associated with expression of SIGLEC10 and PIH1D1. Most significant SNPs in GL were located on SSC6 and associated with expression levels of PIH1D1, SIGLEC10, TBCB, LOC100518735, KIF1B, LOC100514845, and two unknown genes. The abundance of transcripts of these genes in muscle, in turn, is significantly correlated with meat quality traits. We identified several genes with evidence for their candidacy for meat quality arising from the integrative approach of a genome-wide association study and eQTL analysis.
1000 Sacherschließung
lokal pork quality
lokal microarray
lokal GWAS
lokal SNP chip
lokal eQTL
1000 Fachgruppe
  1. Medizin |
  2. Biologie |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
1000 Label
1000 Förderer
  1. German Research Foundation (Deutsche Forschungsgemeinschaft) |
1000 Fördernummer
  1. PO753/7-1; WI1754/14-1
1000 Förderprogramm
  1. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer German Research Foundation (Deutsche Forschungsgemeinschaft) |
    1000 Förderprogramm -
    1000 Fördernummer PO753/7-1; WI1754/14-1
1000 Objektart article
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1000 @id frl:6402919.rdf
1000 Erstellt am 2017-06-07T13:48:40.000+0200
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1000 Zuletzt bearbeitet Fri Jan 31 01:51:29 CET 2020
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