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1000 Titel
  • Neuronal merlin influences ERBB2 receptor expression on Schwann cells through neuregulin 1 type III signalling
1000 Autor/in
  1. Schulz, Alexander |
  2. Kyselyova, Anna |
  3. Baader, Stephan L. |
  4. Jung, Marie Juliane |
  5. Zoch, Ansgar |
  6. Mautner, Victor-Felix |
  7. Hagel, Christian |
  8. Morrison, Helen |
1000 Erscheinungsjahr 2013
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2013-12-05
1000 Erschienen in
1000 Quellenangabe
  • 137(2): 420-432
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2013
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1093/brain/awt327 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914471/ |
1000 Ergänzendes Material
  • https://academic.oup.com/brain/article-lookup/doi/10.1093/brain/awt327#78870548 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Axonal surface proteins encompass a group of heterogeneous molecules, which exert a variety of different functions in the highly interdependent relationship between axons and Schwann cells. We recently revealed that the tumour suppressor protein merlin, mutated in the hereditary tumour syndrome neurofibromatosis type 2, impacts significantly on axon structure maintenance in the peripheral nervous system. We now report on a role of neuronal merlin in the regulation of the axonal surface protein neuregulin 1 important for modulating Schwann cell differentiation and myelination. Specifically, neuregulin 1 type III expression is reduced in sciatic nerve tissue of neuron-specific knockout animals as well as in biopsies from seven patients with neurofibromatosis type 2. In vitro experiments performed on both the P19 neuronal cell line and primary dorsal root ganglion cells demonstrate the influence of merlin on neuregulin 1 type III expression. Moreover, expression of ERBB2, a Schwann cell receptor for neuregulin 1 ligands is increased in nerve tissue of both neuron-specific merlin knockout animals and patients with neurofibromatosis type 2, demonstrating for the first time that axonal merlin indirectly regulates Schwann cell behaviour. Collectively, we have identified that neuronally expressed merlin can influence Schwann cell activity in a cell-extrinsic manner.
1000 Sacherschließung
lokal merlin
lokal Schwann cell
lokal polyneuropathy
lokal myelination
lokal neurofibromatosis type 2
lokal axon
lokal neuregulin 1
1000 Fachgruppe
  1. Medizin |
  2. Biologie |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. http://orcid.org/0000-0003-1604-4596|https://frl.publisso.de/adhoc/creator/S3lzZWx5b3ZhLCBBbm5hIA==|https://frl.publisso.de/adhoc/creator/QmFhZGVyLCBTdGVwaGFuIEwu|https://frl.publisso.de/adhoc/creator/SnVuZywgTWFyaWUgSnVsaWFuZSA=|https://frl.publisso.de/adhoc/creator/Wm9jaCwgQW5zZ2FyIA==|https://frl.publisso.de/adhoc/creator/TWF1dG5lciwgVmljdG9yLUZlbGl4IA==|https://frl.publisso.de/adhoc/creator/SGFnZWwsIENocmlzdGlhbiA=|http://orcid.org/0000-0003-4938-1409
1000 Förderer
  1. - |
  2. - |
  3. Krebshilfe |
  4. Young Investigator Award from the Children’s Tumor Foundation (New York, USA) |
1000 Fördernummer
  1. SFB 604
  2. DFG MO 1421/2-1
  3. 107089
  4. -
1000 Förderprogramm
  1. -
  2. -
  3. -
  4. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer - |
    1000 Förderprogramm -
    1000 Fördernummer SFB 604
  2. 1000 joinedFunding-child
    1000 Förderer - |
    1000 Förderprogramm -
    1000 Fördernummer DFG MO 1421/2-1
  3. 1000 joinedFunding-child
    1000 Förderer Krebshilfe |
    1000 Förderprogramm -
    1000 Fördernummer 107089
  4. 1000 joinedFunding-child
    1000 Förderer Young Investigator Award from the Children’s Tumor Foundation (New York, USA) |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6403178.rdf
1000 Erstellt am 2017-06-20T11:22:48.899+0200
1000 Erstellt von 218
1000 beschreibt frl:6403178
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Wed Mar 07 12:48:12 CET 2018
1000 Objekt bearb. Wed Mar 07 12:48:11 CET 2018
1000 Vgl. frl:6403178
1000 Oai Id
  1. oai:frl.publisso.de:frl:6403178 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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