journal.pone.0021691.PDF 348,59KB
1000 Titel
  • A High Protein Diet during Pregnancy Affects Hepatic Gene Expression of Energy Sensing Pathways along Ontogenesis in a Porcine Model
1000 Autor/in
  1. Oster, Michael |
  2. Murani, Eduard |
  3. Metges, Cornelia C. |
  4. Ponsuksili, Siriluck |
  5. Wimmers, Klaus |
1000 Erscheinungsjahr 2011
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2011-07-18
1000 Erschienen in
1000 Quellenangabe
  • 6(7): e21691
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2011
1000 Lizenz
1000 Verlagsversion
  • |
  • |
1000 Ergänzendes Material
  • |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • In rodent models and in humans the impact of gestational diets on the offspring's phenotype was shown experimentally and epidemiologically. The underlying programming of fetal development was shown to be associated with an increased risk of degenerative diseases in adulthood, including the metabolic syndrome. There are clues that diet-dependent modifications of the metabolism during fetal life can persist until adulthood. This leads to the hypothesis that the offspring's transcriptomes show short-term and long-term changes depending on the maternal diet. To this end pregnant German landrace gilts were fed either a high protein diet (HP, 30% CP) or an adequate protein diet (AP, 12% CP) throughout pregnancy. Hepatic transcriptome profiles of the offspring were analyzed at prenatal (94 dpc) and postnatal stages (1, 28, 188 dpn). Depending on the gestational dietary exposure, mRNA expression levels of genes related to energy metabolism, N-metabolism, growth factor signaling pathways, lipid metabolism, nucleic acid metabolism and stress/immune response were affected either in a short-term or in a long-term manner. Gene expression profiles at fetal stage 94 dpc were almost unchanged between the diets. The gestational HP diet affected the hepatic expression profiles at prenatal and postnatal stages. The effects encompassed a modulation of the genome in terms of an altered responsiveness of energy and nutrient sensing pathways. Differential expression of genes related to energy production and nutrient utilization contribute to the maintenance of development and growth performance within physiological norms, however the modulation of these pathways may be accompanied by a predisposition for metabolic disturbances up to adult stages.
1000 Sacherschließung
lokal Mitochondria
lokal Transcriptome analysis
lokal Diet
lokal Swine
lokal Gene regulation
lokal Gene expression
lokal Hormone receptor signaling
lokal PPAR signaling
1000 Fachgruppe
  1. Biologie |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
1000 Förderer
  1. German Federal Ministry of Education and Research |
1000 Fördernummer
  1. FKZ 0315132A
1000 Förderprogramm
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer German Federal Ministry of Education and Research |
    1000 Förderprogramm FEPROeXPRESS (FUGATO plus)
    1000 Fördernummer FKZ 0315132A
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6403234.rdf
1000 Erstellt am 2017-06-26T12:11:16.562+0200
1000 Erstellt von 21
1000 beschreibt frl:6403234
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Wed Apr 11 10:58:35 CEST 2018
1000 Objekt bearb. Wed Apr 11 10:58:35 CEST 2018
1000 Vgl. frl:6403234
1000 Oai Id
  1. |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source