Download
redirect-nature.pdf 3,66MB
WeightNameValue
1000 Titel
  • Differentiating Staphylococcus aureus from Escherichia coli mastitis: S. aureus triggers unbalanced immune-dampening and host cell invasion immediately after udder infection
1000 Autor/in
  1. Günther, Juliane |
  2. Petzl, Wolfram |
  3. Bauer, Isabel |
  4. Ponsuksili, Siriluck |
  5. Zerbe, Holm |
  6. Schuberth, Hans-Joachim |
  7. Brunner, Ronald M. |
  8. Seyfert, Hans-Martin |
1000 Erscheinungsjahr 2017
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2017-07-06
1000 Erschienen in
1000 Quellenangabe
  • 7: 4811
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2017
1000 Lizenz
1000 Verlagsversion
  • http://doi.org/10.1038/s41598-017-05107-4 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500526/ |
1000 Ergänzendes Material
  • https://www.nature.com/articles/s41598-017-05107-4#supplementary-information |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The etiology determines quality and extent of the immune response after udder infection (mastitis). Infections with Gram negative bacteria (e.g. Escherichia coli) will quickly elicit strong inflammation of the udder, fully activate its immune defence via pathogen receptor driven activation of IκB/NF-κB signaling. This often eradicates the pathogen. In contrast, Gram-positive bacteria (e.g. Staphylococcus aureus) will slowly elicit a much weaker inflammation and immune response, frequently resulting in chronic infections. However, it was unclear which immune regulatory pathways are specifically triggered by S. aureus causing this partial immune subversion. We therefore compared in first lactating cows the earliest (1–3 h) udder responses against infection with mastitis causing pathogens of either species. Global transcriptome profiling, bioinformatics analysis and experimental validation of key aspects revealed as S. aureus infection specific features the (i) failure to activating IκB/NF-κB signaling; (ii) activation of the wnt/β-catenin cascade resulting in active suppression of NF-κB signaling and (iii) rearrangement of the actin-cytoskeleton through modulating Rho GTPase regulated pathways. This facilitates invasion of pathogens into host cells. Hence, S. aureus mastitis is characterized by eliciting unbalanced immune suppression rather than inflammation and invasion of S. aureus into the epithelial cells of the host causing sustained infection.
1000 Fachgruppe
  1. Medizin |
  2. Biologie |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/R8O8bnRoZXIswqBKdWxpYW5l|https://frl.publisso.de/adhoc/creator/UGV0emwswqBXb2xmcmFt|https://frl.publisso.de/adhoc/creator/QmF1ZXIswqBJc2FiZWw=|https://frl.publisso.de/adhoc/creator/UG9uc3Vrc2lsaSzCoFNpcmlsdWNr|https://frl.publisso.de/adhoc/creator/WmVyYmUswqBIb2xt|https://frl.publisso.de/adhoc/creator/U2NodWJlcnRoLMKgSGFucy1Kb2FjaGlt|https://frl.publisso.de/adhoc/creator/QnJ1bm5lciwgUm9uYWxkIE0u|https://frl.publisso.de/adhoc/creator/U2V5ZmVydCwgSGFucy1NYXJ0aW4=
1000 Förderer
  1. German Research Foundation (DFG) |
1000 Fördernummer
  1. FOR 585; GU 1487/1-1
1000 Förderprogramm
  1. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer German Research Foundation (DFG) |
    1000 Förderprogramm -
    1000 Fördernummer FOR 585; GU 1487/1-1
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6403498.rdf
1000 Erstellt am 2017-07-17T12:03:45.354+0200
1000 Erstellt von 25
1000 beschreibt frl:6403498
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Thu Sep 27 13:43:06 CEST 2018
1000 Objekt bearb. Thu Sep 27 13:43:05 CEST 2018
1000 Vgl. frl:6403498
1000 Oai Id
  1. oai:frl.publisso.de:frl:6403498 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source