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WeightNameValue
1000 Titel
  • Claudins are essential for cell shape changes and convergent extension movements during neural tube closure
1000 Autor/in
  1. Baumholtz, Amanda I. |
  2. Simard, Annie |
  3. Nikolopoulou, Evanthia |
  4. Oosenbrug, Marcus |
  5. Collins, Michelle M. |
  6. Piontek, Anna |
  7. Krause, Gerd |
  8. Piontek, Jörg |
  9. Greene, Nicholas D.E. |
  10. Ryan, Aimee K. |
1000 Erscheinungsjahr 2017
1000 LeibnizOpen
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2017-05-22
1000 Erschienen in
1000 Quellenangabe
  • 428(1): 25-38
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2017
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1016/j.ydbio.2017.05.013 |
  • https://www.ncbi.nlm.nih.gov/pubmed/28545845 |
1000 Ergänzendes Material
  • http://www.sciencedirect.com/science/article/pii/S0012160617300441?via%3Dihub#s0120 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • During neural tube closure, regulated changes at the level of individual cells are translated into large-scale morphogenetic movements to facilitate conversion of the flat neural plate into a closed tube. Throughout this process, the integrity of the neural epithelium is maintained via cell interactions through intercellular junctions, including apical tight junctions. Members of the claudin family of tight junction proteins regulate paracellular permeability, apical-basal cell polarity and link the tight junction to the actin cytoskeleton. Here, we show that claudins are essential for neural tube closure: the simultaneous removal of Cldn3, −4 and −8 from tight junctions caused folate-resistant open neural tube defects. Their removal did not affect cell type differentiation, neural ectoderm patterning nor overall apical-basal polarity. However, apical accumulation of Vangl2, RhoA, and pMLC were reduced, and Par3 and Cdc42 were mislocalized at the apical cell surface. Our data showed that claudins act upstream of planar cell polarity and RhoA/ROCK signaling to regulate cell intercalation and actin-myosin contraction, which are required for convergent extension and apical constriction during neural tube closure, respectively.
1000 Sacherschließung
lokal Convergent extension
lokal Apical constriction
lokal Tight junctions
lokal Claudin
lokal Neural tube defects
1000 Fachgruppe
  1. Biologie |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/QmF1bWhvbHR6LCBBbWFuZGEgSS4=|https://frl.publisso.de/adhoc/creator/U2ltYXJkLCBBbm5pZQ==|https://frl.publisso.de/adhoc/creator/Tmlrb2xvcG91bG91LCBFdmFudGhpYQ==|https://frl.publisso.de/adhoc/creator/T29zZW5icnVnLCBNYXJjdXM=|https://frl.publisso.de/adhoc/creator/Q29sbGlucywgTWljaGVsbGUgTS4=|https://frl.publisso.de/adhoc/creator/UGlvbnRlaywgQW5uYQ==|https://frl.publisso.de/adhoc/creator/S3JhdXNlLCBHZXJk|https://frl.publisso.de/adhoc/creator/UGlvbnRlaywgSsO2cmc=|https://frl.publisso.de/adhoc/creator/R3JlZW5lLCBOaWNob2xhcyBELkUu|https://frl.publisso.de/adhoc/creator/UnlhbiwgQWltZWUgSy4=
1000 Förderer
  1. - |
  2. UK Medical Research Council (NDEG) |
  3. Deutsche Forschungsgemeinschaft |
  4. Natural Sciences and Engineering Research Council of Canada |
  5. Canadian Institutes of Health Research |
1000 Fördernummer
  1. 29939
  2. G0802163
  3. 1273/3-2; PI 837/2-1
  4. 234319
  5. MOP-84583
1000 Förderprogramm
  1. Fonds de recherche du Québec – Santé (FRQS)
  2. -
  3. -
  4. -
  5. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer - |
    1000 Förderprogramm Fonds de recherche du Québec – Santé (FRQS)
    1000 Fördernummer 29939
  2. 1000 joinedFunding-child
    1000 Förderer UK Medical Research Council (NDEG) |
    1000 Förderprogramm -
    1000 Fördernummer G0802163
  3. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft |
    1000 Förderprogramm -
    1000 Fördernummer 1273/3-2; PI 837/2-1
  4. 1000 joinedFunding-child
    1000 Förderer Natural Sciences and Engineering Research Council of Canada |
    1000 Förderprogramm -
    1000 Fördernummer 234319
  5. 1000 joinedFunding-child
    1000 Förderer Canadian Institutes of Health Research |
    1000 Förderprogramm -
    1000 Fördernummer MOP-84583
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6403533.rdf
1000 Erstellt am 2017-07-19T13:30:06.496+0200
1000 Erstellt von 25
1000 beschreibt frl:6403533
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Wed Aug 01 12:13:55 CEST 2018
1000 Objekt bearb. Wed Aug 01 12:13:55 CEST 2018
1000 Vgl. frl:6403533
1000 Oai Id
  1. oai:frl.publisso.de:frl:6403533 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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