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1000 Titel
  • Temporal sampling, resetting, and adaptation orchestrate gradient sensing in sperm
1000 Autor/in
  1. Kashikar, Nachiket D. |
  2. Alvarez, Luis |
  3. Seifert, Reinhard |
  4. Gregor, Ingo |
  5. Jäckle, Oliver |
  6. Beyermann, Michael |
  7. Krause, Eberhard |
  8. Kaupp, U. Benjamin |
1000 Erscheinungsjahr 2012
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2012-09-17
1000 Erschienen in
1000 Quellenangabe
  • 198(6): 1075-1091
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2012
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1083/jcb.201204024 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3444779/ |
1000 Ergänzendes Material
  • http://www.jcb.org/cgi/content/full/jcb.201204024/DC1 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Sperm, navigating in a chemical gradient, are exposed to a periodic stream of chemoattractant molecules. The periodic stimulation entrains Ca2+ oscillations that control looping steering responses. It is not known how sperm sample chemoattractant molecules during periodic stimulation and adjust their sensitivity. We report that sea urchin sperm sampled molecules for 0.2–0.6 s before a Ca2+ response was produced. Additional molecules delivered during a Ca2+ response reset the cell by causing a pronounced Ca2+ drop that terminated the response; this reset was followed by a new Ca2+ rise. After stimulation, sperm adapted their sensitivity following the Weber–Fechner law. Taking into account the single-molecule sensitivity, we estimate that sperm can register a minimal gradient of 0.8 fM/µm and be attracted from as far away as 4.7 mm. Many microorganisms sense stimulus gradients along periodic paths to translate a spatial distribution of the stimulus into a temporal pattern of the cell response. Orchestration of temporal sampling, resetting, and adaptation might control gradient sensing in such organisms as well.
1000 Fachgruppe
  1. Biologie |
  2. Medizin |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/S2FzaGlrYXIsIE5hY2hpa2V0IEQu|https://frl.publisso.de/adhoc/creator/QWx2YXJleiwgTHVpcw==|https://frl.publisso.de/adhoc/creator/U2VpZmVydCwgUmVpbmhhcmQ=|https://frl.publisso.de/adhoc/creator/R3JlZ29yLCBJbmdv|https://frl.publisso.de/adhoc/creator/SsOkY2tsZSwgT2xpdmVy|https://frl.publisso.de/adhoc/creator/QmV5ZXJtYW5uLCBNaWNoYWVs|https://frl.publisso.de/adhoc/creator/S3JhdXNlLCBFYmVyaGFyZA==|https://frl.publisso.de/adhoc/creator/S2F1cHAsIFUuIEJlbmphbWlu
1000 Förderer
  1. German Research Foundation |
  2. - |
1000 Fördernummer
  1. -
  2. -
1000 Förderprogramm
  1. -
  2. Fonds der Chemischen Industrie
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer German Research Foundation |
    1000 Förderprogramm -
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer - |
    1000 Förderprogramm Fonds der Chemischen Industrie
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6403551.rdf
1000 Erstellt am 2017-07-24T09:19:45.407+0200
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1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Wed Jun 20 13:30:03 CEST 2018
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1000 Vgl. frl:6403551
1000 Oai Id
  1. oai:frl.publisso.de:frl:6403551 |
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