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1000 Titel
  • Habenula and interpeduncular nucleus differentially modulate predator odor-induced innate fear behavior in rats
1000 Autor/in
  1. Vincenz, Daniel |
  2. Wernecke, Kerstin E.A. |
  3. Fendt, Markus |
  4. Goldschmidt, Jürgen |
1000 Erscheinungsjahr 2017
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2017-05-26
1000 Erschienen in
1000 Quellenangabe
  • 332: 164-171
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2017
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1016/j.bbr.2017.05.053 |
1000 Ergänzendes Material
  • http://www.sciencedirect.com/science/article/pii/S0166432817302942?via%3Dihub#sec0095 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Fear is an important behavioral system helping humans and animals to survive potentially dangerous situations. Fear can be innate or learned. Whereas the neural circuits underlying learned fear are already well investigated, the knowledge about the circuits mediating innate fear is still limited. We here used a novel, unbiased approach to image in vivo the spatial patterns of neural activity in odor-induced innate fear behavior in rats. We intravenously injected awake unrestrained rats with a 99m-technetium labeled blood flow tracer (99mTc-HMPAO) during ongoing exposure to fox urine or water as control, and mapped the brain distribution of the trapped tracer using single-photon emission computed tomography (SPECT). Upon fox urine exposure blood flow increased in a number of brain regions previously associated with odor-induced innate fear such as the amygdala, ventromedial hypothalamus and dorsolateral periaqueductal grey, but, unexpectedly, decreased at higher significance levels in the interpeduncular nucleus (IPN). Significant flow changes were found in regions monosynaptically connected to the IPN. Flow decreased in the dorsal tegmentum and entorhinal cortex. Flow increased in the habenula (Hb) and correlated with odor effects on behavioral defensive strategy. Hb lesions reduced avoidance of but increased approach to the fox urine while IPN lesions only reduced avoidance behavior without approach behavior. Our study identifies a new component, the IPN, of the neural circuit mediating odor-induced innate fear behavior in mammals and suggests that the evolutionarily conserved Hb-IPN system, which has recently been implicated in cued fear, also forms an integral part of the innate fear circuitry.
1000 Sacherschließung
lokal Defensive strategy
lokal Risk assessment
lokal Avoidance
lokal Habenulo-interpeduncular system
lokal Lesion
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/VmluY2VueiwgRGFuaWVs|https://frl.publisso.de/adhoc/creator/V2VybmVja2UsIEtlcnN0aW4gRS5BLg==|https://frl.publisso.de/adhoc/creator/RmVuZHQsIE1hcmt1cw==|https://frl.publisso.de/adhoc/creator/R29sZHNjaG1pZHQsIErDvHJnZW4=
1000 Label
1000 Förderer
  1. Federal state of Saxony-Anhalt |
1000 Fördernummer
  1. -
1000 Förderprogramm
  1. Center for Behavioral Brain Sciences (CBBS)
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Federal state of Saxony-Anhalt |
    1000 Förderprogramm Center for Behavioral Brain Sciences (CBBS)
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6403609.rdf
1000 Erstellt am 2017-07-31T14:03:48.657+0200
1000 Erstellt von 25
1000 beschreibt frl:6403609
1000 Bearbeitet von 288
1000 Zuletzt bearbeitet Thu Aug 18 07:55:10 CEST 2022
1000 Objekt bearb. Wed Mar 31 09:18:47 CEST 2021
1000 Vgl. frl:6403609
1000 Oai Id
  1. oai:frl.publisso.de:frl:6403609 |
1000 Sichtbarkeit Metadaten public
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