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1000 Titel
  • Synaptic GluN2B/CaMKII-α Signaling Induces Synapto-Nuclear Transport of ERK and Jacob
1000 Autor/in
  1. Melgarejo da Rosa, Michelle |
  2. Yuanxiang, PingAn |
  3. Brambilla, Riccardo |
  4. Kreutz, Michael R. |
  5. Karpova, Anna |
1000 Erscheinungsjahr 2016
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2016-08-11
1000 Erschienen in
1000 Quellenangabe
  • 9:66
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2016
1000 Lizenz
1000 Verlagsversion
  • http://dx.doi.org/10.3389/fnmol.2016.00066 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978723/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • A central pathway in synaptic plasticity couples N-Methyl-D-Aspartate-receptor (NMDAR)-signaling to the activation of extracellular signal-regulated kinases (ERKs) cascade. ERK-dependency has been demonstrated for several forms of synaptic plasticity as well as learning and memory and includes local synaptic processes but also long-distance signaling to the nucleus. It is, however, controversial how NMDAR signals are connected to ERK activation in dendritic spines and nuclear import of ERK. The synapto-nuclear messenger Jacob couples NMDAR-dependent Ca(2+)-signaling to CREB-mediated gene expression. Protein transport of Jacob from synapse to nucleus essentially requires activation of GluN2B-containing NMDARs. Subsequent phosphorylation and binding of ERK1/2 to and ERK-dependent phosphorylation of serine 180 in Jacob encodes synaptic but not extrasynaptic NMDAR activation. In this study we show that stimulation of synaptic NMDAR in hippocampal primary neurons and induction of long-term potentiation (LTP) in acute slices results in GluN2B-dependent activation of CaMKII-α and subsequent nuclear import of active ERK and serine 180 phosphorylated Jacob. On the contrary, no evidence was found that either GluN2A-containing NMDAR or RasGRF2 are upstream of ERK activation and nuclear import of Jacob and ERK.
1000 Sacherschließung
lokal synapse-to-nucleus
lokal ERK1/2
lokal RasGRF2
lokal Jacob/NSMF
lokal GluN2B
lokal CaMKII-α
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/TWVsZ2FyZWpvIGRhIFJvc2EsIE1pY2hlbGxl|https://frl.publisso.de/adhoc/creator/WXVhbnhpYW5nLCBQaW5nQW4=|https://frl.publisso.de/adhoc/creator/QnJhbWJpbGxhLCBSaWNjYXJkbw==|https://frl.publisso.de/adhoc/creator/S3JldXR6LCBNaWNoYWVsIFIu|https://frl.publisso.de/adhoc/creator/S2FycG92YSwgQW5uYQ==
1000 Label
1000 Förderer
  1. Deutsche Forschungsgemeinschaft (DFG) |
  2. JPND STAD |
  3. Federal State of Saxony-Anhalt, Center for Behavioral Brain Sciences (CBBS) |
  4. Fondazione Mariani for Neurological Disorders |
  5. Michael J. Fox Foundation for Parkinson's Research |
  6. Parkinson's UK |
  7. Italian Ministry of Health |
  8. CARIPLO Foundation |
1000 Fördernummer
  1. Kr1879/5-1, 6-1; SFB779 TPB8
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  3. -
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1000 Förderprogramm
  1. -
  2. -
  3. NeuroNetwork #5
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  5. -
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1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft (DFG) |
    1000 Förderprogramm -
    1000 Fördernummer Kr1879/5-1, 6-1; SFB779 TPB8
  2. 1000 joinedFunding-child
    1000 Förderer JPND STAD |
    1000 Förderprogramm -
    1000 Fördernummer -
  3. 1000 joinedFunding-child
    1000 Förderer Federal State of Saxony-Anhalt, Center for Behavioral Brain Sciences (CBBS) |
    1000 Förderprogramm NeuroNetwork #5
    1000 Fördernummer -
  4. 1000 joinedFunding-child
    1000 Förderer Fondazione Mariani for Neurological Disorders |
    1000 Förderprogramm -
    1000 Fördernummer -
  5. 1000 joinedFunding-child
    1000 Förderer Michael J. Fox Foundation for Parkinson's Research |
    1000 Förderprogramm -
    1000 Fördernummer -
  6. 1000 joinedFunding-child
    1000 Förderer Parkinson's UK |
    1000 Förderprogramm -
    1000 Fördernummer -
  7. 1000 joinedFunding-child
    1000 Förderer Italian Ministry of Health |
    1000 Förderprogramm -
    1000 Fördernummer -
  8. 1000 joinedFunding-child
    1000 Förderer CARIPLO Foundation |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6403650.rdf
1000 Erstellt am 2017-08-03T11:19:47.547+0200
1000 Erstellt von 122
1000 beschreibt frl:6403650
1000 Bearbeitet von 288
1000 Zuletzt bearbeitet Mon Mar 01 08:57:20 CET 2021
1000 Objekt bearb. Mon Mar 01 08:57:20 CET 2021
1000 Vgl. frl:6403650
1000 Oai Id
  1. oai:frl.publisso.de:frl:6403650 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
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