Download
journal.pone.0159718.PDF 12,37MB
WeightNameValue
1000 Titel
  • Neuron-Specific Deletion of the Nf2 Tumor Suppressor Impairs Functional Nerve Regeneration
1000 Autor/in
  1. Schulz, Alexander |
  2. Büttner, Robert |
  3. Toledo, Andrea |
  4. Baader, Stephan L. |
  5. von Maltzahn, Julia |
  6. Irintchev, Andrey |
  7. Bauer, Reinhard |
  8. Morrison, Helen |
1000 Erscheinungsjahr 2016
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2016-07-28
1000 Erschienen in
1000 Quellenangabe
  • 11(7):e0159718
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2016
1000 Lizenz
1000 Verlagsversion
  • http://dx.doi.org/10.1371/journal.pone.0159718 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4965074/ |
1000 Ergänzendes Material
  • http://journals.plos.org/plosone/article/asset?unique&id=info%3Adoi/10.1371/journal.pone.0159718.s001 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • In contrast to axons of the central nervous system (CNS), axons of the peripheral nervous system (PNS) show better, but still incomplete and often slow regeneration following injury. The tumor suppressor protein merlin, mutated in the hereditary tumor syndrome Neurofibromatosis type 2 (NF2), has recently been shown to have RhoA regulatory functions in PNS neurons—in addition to its well-characterized, growth-inhibitory activity in Schwann cells. Here we report that the conditional knockout of merlin in PNS neurons leads to impaired functional recovery of mice following sciatic nerve crush injury, in a gene-dosage dependent manner. Gross anatomical or electrophysiological alterations of sciatic nerves could not be detected. However, correlating with attenuated RhoA activation due to merlin deletion, ultrastructural analysis of nerve samples indicated enhanced sprouting of axons with reduced caliber size and increased myelination compared to wildtype animals. We conclude that deletion of the tumor suppressor merlin in the neuronal compartment of peripheral nerves results in compromised functional regeneration after injury. This mechanism could explain the clinical observation that NF2 patients suffer from higher incidences of slowly recovering facial nerve paralysis after vestibular schwannoma surgery.
1000 Sacherschließung
lokal Axons
lokal Nerve fibers
lokal Neurons
lokal Sciatic nerves
lokal Nerves
lokal Neurofibromatosis type 2
lokal Nerve regeneration
lokal Muscle electrophysiology
1000 Fachgruppe
  1. Biologie |
  2. Medizin |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. http://orcid.org/0000-0003-1604-4596|http://orcid.org/0000-0002-4337-4251|https://frl.publisso.de/adhoc/creator/VG9sZWRvLCBBbmRyZWE=|https://frl.publisso.de/adhoc/creator/QmFhZGVyLCBTdGVwaGFuIEwu|http://orcid.org/0000-0001-7674-1487|https://frl.publisso.de/adhoc/creator/SXJpbnRjaGV2LCBBbmRyZXk=|https://frl.publisso.de/adhoc/creator/QmF1ZXIsIFJlaW5oYXJk|http://orcid.org/0000-0003-4938-1409
1000 Förderer
  1. Deutsche Forschungsgemeinschaft (DFG) |
  2. Deutsche Krebshilfe |
  3. Children’s Tumor Foundation |
  4. Alexander von Humboldt foundation |
1000 Fördernummer
  1. SFB 604; MO 1421/2-1; RTG1715; MA-3975/2-1
  2. 107089
  3. 2015-05-010
  4. -
1000 Förderprogramm
  1. -
  2. -
  3. Drug Discovery Award
  4. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft (DFG) |
    1000 Förderprogramm -
    1000 Fördernummer SFB 604; MO 1421/2-1; RTG1715; MA-3975/2-1
  2. 1000 joinedFunding-child
    1000 Förderer Deutsche Krebshilfe |
    1000 Förderprogramm -
    1000 Fördernummer 107089
  3. 1000 joinedFunding-child
    1000 Förderer Children’s Tumor Foundation |
    1000 Förderprogramm Drug Discovery Award
    1000 Fördernummer 2015-05-010
  4. 1000 joinedFunding-child
    1000 Förderer Alexander von Humboldt foundation |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6403686.rdf
1000 Erstellt am 2017-08-08T09:46:26.491+0200
1000 Erstellt von 122
1000 beschreibt frl:6403686
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Wed Mar 07 12:41:16 CET 2018
1000 Objekt bearb. Wed Mar 07 12:41:16 CET 2018
1000 Vgl. frl:6403686
1000 Oai Id
  1. oai:frl.publisso.de:frl:6403686 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

View source