Non-steroidal anti-inflammatory drugs and risk of heart failure in four European countries: Nested case-control study

  1. Arfè, Andrea
  2. Scotti, Lorenza
  3. Varas-Lorenzo, Cristina
  4. Nicotra, Federica
  5. Zambon, Antonella
  6. Kollhorst, Bianca
  7. Schink, Tania
  8. Garbe, Edeltraut
  9. Herings, Ron
  10. Straatman, Huub
  11. Schade, René
  12. Villa, Marco
  13. Lucchi, Silvia
  14. Valkhoff, Vera
  15. Romio, Silvana
  16. Thiessard, Frantz
  17. Schuemie, Martijn
  18. Pariente, Antoine
  19. Sturkenboom, Miriam
  20. Corrao, Giovanni

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WeightNameValue
1000 Titel
  • Non-steroidal anti-inflammatory drugs and risk of heart failure in four European countries: Nested case-control study
1000 Autor/in
  1. Arfè, Andrea |
  2. Scotti, Lorenza |
  3. Varas-Lorenzo, Cristina |
  4. Nicotra, Federica |
  5. Zambon, Antonella |
  6. Kollhorst, Bianca |
  7. Schink, Tania |
  8. Garbe, Edeltraut |
  9. Herings, Ron |
  10. Straatman, Huub |
  11. Schade, René |
  12. Villa, Marco |
  13. Lucchi, Silvia |
  14. Valkhoff, Vera |
  15. Romio, Silvana |
  16. Thiessard, Frantz |
  17. Schuemie, Martijn |
  18. Pariente, Antoine |
  19. Sturkenboom, Miriam |
  20. Corrao, Giovanni |
1000 Mitwirkende/r
  1. Safety of Non-steroidal Anti-inflammatory Drugs (SOS) Project Consortium |
1000 Erscheinungsjahr 2016
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2016-09-28
1000 Erschienen in
1000 Quellenangabe
  • 354:i4857
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2016
1000 Lizenz
1000 Verlagsversion
  • http://dx.doi.org/10.1136/bmj.i4857 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • OBJECTIVES: To investigate the cardiovascular safety of non-steroidal anti-inflammatory drugs (NSAIDs) and estimate the risk of hospital admission for heart failure with use of individual NSAIDs. DESIGN: Nested case-control study. SETTING: Five population based healthcare databases from four European countries (the Netherlands, Italy, Germany, and the United Kingdom). PARTICIPANTS: Adult individuals (age ≥18 years) who started NSAID treatment in 2000-10. Overall, 92 163 hospital admissions for heart failure were identified and matched with 8 246 403 controls (matched via risk set sampling according to age, sex, year of cohort entry). MAIN OUTCOME MEASURE: Association between risk of hospital admission for heart failure and use of 27 individual NSAIDs, including 23 traditional NSAIDs and four selective COX 2 inhibitors. Associations were assessed by multivariable conditional logistic regression models. The dose-response relation between NSAID use and heart failure risk was also assessed. RESULTS: Current use of any NSAID (use in preceding 14 days) was found to be associated with a 19% increase of risk of hospital admission for heart failure (adjusted odds ratio 1.19; 95% confidence interval 1.17 to 1.22), compared with past use of any NSAIDs (use >183 days in the past). Risk of admission for heart failure increased for seven traditional NSAIDs (diclofenac, ibuprofen, indomethacin, ketorolac, naproxen, nimesulide, and piroxicam) and two COX 2 inhibitors (etoricoxib and rofecoxib). Odds ratios ranged from 1.16 (95% confidence interval 1.07 to 1.27) for naproxen to 1.83 (1.66 to 2.02) for ketorolac. Risk of heart failure doubled for diclofenac, etoricoxib, indomethacin, piroxicam, and rofecoxib used at very high doses (≥2 defined daily dose equivalents), although some confidence intervals were wide. Even medium doses (0.9-1.2 defined daily dose equivalents) of indomethacin and etoricoxib were associated with increased risk. There was no evidence that celecoxib increased the risk of admission for heart failure at commonly used doses. CONCLUSIONS: The risk of hospital admission for heart failure associated with current use of NSAIDs appears to vary between individual NSAIDs, and this effect is dose dependent. This risk is associated with the use of a large number of individual NSAIDs reported by this study, which could help to inform both clinicians and health regulators.
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1000 Liste der Beteiligten
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1000 Label
1000 Förderer
  1. European Community’s seventh Framework Programme |
1000 Fördernummer
  1. 223495
1000 Förderprogramm
  1. SOS Project
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer European Community’s seventh Framework Programme |
    1000 Förderprogramm SOS Project
    1000 Fördernummer 223495
1000 Objektart article
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1000 @id frl:6403888.rdf
1000 Erstellt am 2017-08-15T12:21:24.383+0200
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1000 Zuletzt bearbeitet 2021-03-31T09:41:12.668+0200
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  1. oai:frl.publisso.de:frl:6403888 |
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