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1000 Titel
  • Higher plasma levels of lysophosphatidylcholine 18:0 are related to a lower risk of common cancers in a prospective metabolomics study
1000 Autor/in
  1. Kühn, Tilman |
  2. Floegel, Anna |
  3. Sookthai, Disorn |
  4. Johnson, Theron |
  5. Rolle-Kampczyk, Ulrike |
  6. Otto, Wolfgang |
  7. von Bergen, Martin |
  8. Böing, Heiner |
  9. Kaaks, Rudolf |
1000 Erscheinungsjahr 2016
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2016-01-28
1000 Erschienen in
1000 Quellenangabe
  • 14:13
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2016
1000 Lizenz
1000 Verlagsversion
  • https://dx.doi.org/10.1186/s12916-016-0552-3 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4730724/ |
1000 Ergänzendes Material
  • https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-016-0552-3#Declarations |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: First metabolomics studies have indicated that metabolic fingerprints from accessible tissues might be useful to better understand the etiological links between metabolism and cancer. However, there is still a lack of prospective metabolomics studies on pre-diagnostic metabolic alterations and cancer risk. METHODS: Associations between pre-diagnostic levels of 120 circulating metabolites (acylcarnitines, amino acids, biogenic amines, phosphatidylcholines, sphingolipids, and hexoses) and the risks of breast, prostate, and colorectal cancer were evaluated by Cox regression analyses using data of a prospective case-cohort study including 835 incident cancer cases. RESULTS: The median follow-up duration was 8.3 years among non-cases and 6.5 years among incident cases of cancer. Higher levels of lysophosphatidylcholines (lysoPCs), and especially lysoPC a C18:0, were consistently related to lower risks of breast, prostate, and colorectal cancer, independent of background factors. In contrast, higher levels of phosphatidylcholine PC ae C30:0 were associated with increased cancer risk. There was no heterogeneity in the observed associations by lag time between blood draw and cancer diagnosis. CONCLUSION: Changes in blood lipid composition precede the diagnosis of common malignancies by several years. Considering the consistency of the present results across three cancer types the observed alterations point to a global metabolic shift in phosphatidylcholine metabolism that may drive tumorigenesis.
1000 Sacherschließung
lokal Metabolomics
lokal Colorectal cancer
lokal Breast cancer
lokal Epidemiology
lokal Prostate cancer
1000 Fachgruppe
  1. Medizin |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/S8O8aG4sIFRpbG1hbg==|http://d-nb.info/gnd/1118006844|https://frl.publisso.de/adhoc/creator/U29va3RoYWksIERpc29ybg==|https://frl.publisso.de/adhoc/creator/Sm9obnNvbiwgVGhlcm9u|https://frl.publisso.de/adhoc/creator/Um9sbGUtS2FtcGN6eWssIFVscmlrZQ==|https://frl.publisso.de/adhoc/creator/T3R0bywgV29sZmdhbmc=|https://frl.publisso.de/adhoc/creator/dm9uIEJlcmdlbiwgTWFydGlu|http://d-nb.info/gnd/1111919534|https://frl.publisso.de/adhoc/creator/S2Fha3MsIFJ1ZG9sZg==
1000 Förderer
  1. Helmholtz Association |
  2. German Federal Ministry of Education and Research (BMBF) |
1000 Fördernummer
  1. -
  2. 01ER0809
1000 Förderprogramm
  1. portfolio theme “metabolic dysfunction”
  2. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Helmholtz Association |
    1000 Förderprogramm portfolio theme “metabolic dysfunction”
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer German Federal Ministry of Education and Research (BMBF) |
    1000 Förderprogramm -
    1000 Fördernummer 01ER0809
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6404060.rdf
1000 Erstellt am 2017-08-21T13:27:19.545+0200
1000 Erstellt von 122
1000 beschreibt frl:6404060
1000 Bearbeitet von 25
1000 Zuletzt bearbeitet Fri Jul 27 11:15:16 CEST 2018
1000 Objekt bearb. Fri Jul 27 11:15:15 CEST 2018
1000 Vgl. frl:6404060
1000 Oai Id
  1. oai:frl.publisso.de:frl:6404060 |
1000 Sichtbarkeit Metadaten public
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1000 Gegenstand von

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