Synaptopathies: synaptic dysfunction in neurological disorders – A review from students to students

  1. Lepeta, Katarzyna
  2. Lourenco, Mychael V.
  3. Schweitzer, Barbara C.
  4. Martino Adami, Pamela V.
  5. Banerjee, Priyanjalee
  6. Catuara-Solarz, Silvina
  7. de La Fuente Revenga, Mario
  8. Guillem, Alain Marc
  9. Haidar, Mouna
  10. Ijomone, Omamuyovwi M.
  11. Nadorp, Bettina
  12. Qi, Lin
  13. Perera, Nirma D.
  14. Refsgaard, Louise K.
  15. Reid, Kimberley M.
  16. Sabbar, Mariam
  17. Sahoo, Arghyadip
  18. Schaefer, Natascha
  19. Sheean, Rebecca K.
  20. Suska, Anna
  21. Verma, Rajkumar
  22. Vicidomini, Cinzia
  23. Wright, Dean
  24. Zhang, Xing-Ding
  25. Seidenbecher, Constanze

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WeightNameValue
1000 Titel
  • Synaptopathies: synaptic dysfunction in neurological disorders – A review from students to students
1000 Autor/in
  1. Lepeta, Katarzyna |
  2. Lourenco, Mychael V. |
  3. Schweitzer, Barbara C. |
  4. Martino Adami, Pamela V. |
  5. Banerjee, Priyanjalee |
  6. Catuara-Solarz, Silvina |
  7. de La Fuente Revenga, Mario |
  8. Guillem, Alain Marc |
  9. Haidar, Mouna |
  10. Ijomone, Omamuyovwi M. |
  11. Nadorp, Bettina |
  12. Qi, Lin |
  13. Perera, Nirma D. |
  14. Refsgaard, Louise K. |
  15. Reid, Kimberley M. |
  16. Sabbar, Mariam |
  17. Sahoo, Arghyadip |
  18. Schaefer, Natascha |
  19. Sheean, Rebecca K. |
  20. Suska, Anna |
  21. Verma, Rajkumar |
  22. Vicidomini, Cinzia |
  23. Wright, Dean |
  24. Zhang, Xing-Ding |
  25. Seidenbecher, Constanze |
1000 Erscheinungsjahr 2016
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2016-09-08
1000 Erschienen in
1000 Quellenangabe
  • 138(6): 785-805
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2016
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1111/jnc.13713 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095804/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Synapses are essential components of neurons and allow information to travel coordinately throughout the nervous system to adjust behavior to environmental stimuli and to control body functions, memories, and emotions. Thus, optimal synaptic communication is required for proper brain physiology, and slight perturbations of synapse function can lead to brain disorders. In fact, increasing evidence has demonstrated the relevance of synapse dysfunction as a major determinant of many neurological diseases. This notion has led to the concept of synaptopathies as brain diseases with synapse defects as shared pathogenic features. In this review, which was initiated at the 13th International Society for Neurochemistry Advanced School, we discuss basic concepts of synapse structure and function, and provide a critical view of how aberrant synapse physiology may contribute to neurodevelopmental disorders (autism, Down syndrome, startle disease, and epilepsy) as well as neurodegenerative disorders (Alzheimer and Parkinson disease). We finally discuss the appropriateness and potential implications of gathering synapse diseases under a single term. Understanding common causes and intrinsic differences in disease-associated synaptic dysfunction could offer novel clues toward synapse-based therapeutic intervention for neurological and neuropsychiatric disorders. In this Review, which was initiated at the 13th International Society for Neurochemistry (ISN) Advanced School, we discuss basic concepts of synapse structure and function, and provide a critical view of how aberrant synapse physiology may contribute to neurodevelopmental (autism, Down syndrome, startle disease, and epilepsy) as well as neurodegenerative disorders (Alzheimer's and Parkinson's diseases), gathered together under the term of synaptopathies.
1000 Sacherschließung
lokal Down syndrome
lokal hyperekplexia
lokal synapses
lokal autism
lokal Alzheimer disease
lokal epilepsy
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1000 Liste der Beteiligten
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1000 Label
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  1. International Society for Neurochemistry (ISN) |
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    1000 Förderer International Society for Neurochemistry (ISN) |
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