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1000 Titel
  • Quercetin Feeding in Newborn Dairy Calves Cannot Compensate Colostrum Deprivation: Study on Metabolic, Antioxidative and Inflammatory Traits
1000 Autor/in
  1. Gruse, Jeannine |
  2. Kanitz, Ellen |
  3. Weitzel, Joachim M. |
  4. Tuchscherer, Armin |
  5. Stefaniak, Tadeusz |
  6. Jawor, Paulina |
  7. Wolffram, Siegfried |
  8. Hammon, Harald M. |
1000 Erscheinungsjahr 2016
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2016-01-11
1000 Erschienen in
1000 Quellenangabe
  • 11(1):e0146932
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2016
1000 Lizenz
1000 Verlagsversion
  • http://dx.doi.org/10.1371/journal.pone.0146932 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709053/ |
1000 Ergänzendes Material
  • http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0146932#sec020 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Immaturity of the neonatal immune system is causative for high morbidity in calves and colostrum intake is crucial for acquiring passive immunity. Pathogenesis is promoted by reactive oxygen species accumulating at birth if counter-regulation is inadequate. The flavonol quercetin exerts antioxidative and anti-inflammatory effects that may enhance neonatal health. The aim of this work was to study effects of quercetin feeding on metabolic, antioxidative and inflammatory parameters in neonatal calves to investigate whether quercetin could compensate for insufficient colostrum supply. Twenty-eight newborn calves were assigned to two dietary groups fed colostrum or milk-based formula on day 1 and 2 and milk replacer thereafter. From day 2 onwards, 7 calves per diet group were additionally fed quercetin aglycone (50 mg/(kg body weight x day)). Blood samples were taken repeatedly to measure plasma concentrations of flavonols, glucose, lactate, total protein, albumin, urea, non-esterified fatty acids, triglycerides, cholesterol, insulin, glucagon, cortisol, immunoglobulins, fibrinogen, haptoglobin and serum amyloid A. Trolox equivalent antioxidative capacity, ferric reducing ability of plasma, thiobarbituric acid reactive species and F2-isoprostanes were analyzed to evaluate plasma antioxidative status. Expression of tumor necrosis factor, interleukin-1a, interleukin-1ß, serum amyloid A, haptoglobin, fibrinogen, C-reactive protein, catalase, glutathione peroxidase and superoxide dismutase mRNA were measured in liver tissue on day 8. Plasma flavonol concentrations were detectable only after quercetin-feeding without differences between colostrum and formula feeding. Plasma glucose, lactate, total protein, immunoglobulins, triglycerides, cholesterol, trolox equivalent antioxidative capacity and thiobarbituric acid reactive species were higher after colostrum feeding. Body temperature, fecal fluidity and plasma concentrations of cortisol and haptoglobin were higher in formula- than in colostrum-fed groups. Hepatic mRNA expression of tumor necrosis factor was higher after quercetin feeding and expression of C-reactive protein was higher after formula feeding. Data confirm that colostrum improves neonatal health and indicate that quercetin feeding cannot compensate for insufficient colostrum supply.
1000 Sacherschließung
lokal Neonates
lokal Plasma proteins
lokal Body weight
lokal Acute phase proteins
lokal Antibodies
lokal Haptoglobins
lokal Inflammation
lokal Blood plasma
1000 Fachgruppe
  1. Biologie |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/R3J1c2UsIEplYW5uaW5l|https://frl.publisso.de/adhoc/creator/S2FuaXR6LCBFbGxlbg==|https://frl.publisso.de/adhoc/creator/V2VpdHplbCwgSm9hY2hpbSBNLg==|https://frl.publisso.de/adhoc/creator/VHVjaHNjaGVyZXIsIEFybWlu|https://frl.publisso.de/adhoc/creator/U3RlZmFuaWFrLCBUYWRldXN6|https://frl.publisso.de/adhoc/creator/SmF3b3IsIFBhdWxpbmE=|https://frl.publisso.de/adhoc/creator/V29sZmZyYW0sIFNpZWdmcmllZA==|https://frl.publisso.de/adhoc/creator/SGFtbW9uLCBIYXJhbGQgTS4=
1000 Label
1000 Förderer
  1. Federal Ministry of Education and Research, Germany (BMBF) |
1000 Fördernummer
  1. 0315538B
1000 Förderprogramm
  1. Food Chain Plus (FoCus)
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Federal Ministry of Education and Research, Germany (BMBF) |
    1000 Förderprogramm Food Chain Plus (FoCus)
    1000 Fördernummer 0315538B
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6404238.rdf
1000 Erstellt am 2017-08-30T10:46:41.241+0200
1000 Erstellt von 122
1000 beschreibt frl:6404238
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Thu Jan 30 18:09:43 CET 2020
1000 Objekt bearb. Mon Jun 18 12:25:03 CEST 2018
1000 Vgl. frl:6404238
1000 Oai Id
  1. oai:frl.publisso.de:frl:6404238 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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