Ring finger protein 10 is a novel synaptonuclear messenger encoding activation of NMDA receptors in hippocampus

  1. Dinamarca, Margarita C.
  2. Guzzetti, Francesca
  3. Karpova, Anna
  4. Lim, Dmitry
  5. Mitro, Nico
  6. Musardo, Stefano
  7. Mellone, Manuela
  8. Marcello, Elena
  9. Stanic, Jennifer
  10. Samaddar, Tanmoy
  11. Burguière, Adeline
  12. Caldarelli, Antonio
  13. Genazzani, Armando A.
  14. Perroy, Julie
  15. Fagni, Laurent
  16. Canonico, Pier Luigi
  17. Kreutz, Michael R.
  18. Gardoni, Fabrizio
  19. Di Luca, Monica

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WeightNameValue
1000 Titel
  • Ring finger protein 10 is a novel synaptonuclear messenger encoding activation of NMDA receptors in hippocampus
1000 Autor/in
  1. Dinamarca, Margarita C. |
  2. Guzzetti, Francesca |
  3. Karpova, Anna |
  4. Lim, Dmitry |
  5. Mitro, Nico |
  6. Musardo, Stefano |
  7. Mellone, Manuela |
  8. Marcello, Elena |
  9. Stanic, Jennifer |
  10. Samaddar, Tanmoy |
  11. Burguière, Adeline |
  12. Caldarelli, Antonio |
  13. Genazzani, Armando A. |
  14. Perroy, Julie |
  15. Fagni, Laurent |
  16. Canonico, Pier Luigi |
  17. Kreutz, Michael R. |
  18. Gardoni, Fabrizio |
  19. Di Luca, Monica |
1000 Erscheinungsjahr 2016
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2016-03-15
1000 Erschienen in
1000 Quellenangabe
  • 5: e12430
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2016
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.7554/eLife.12430 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4805553/ |
1000 Ergänzendes Material
  • https://elifesciences.org/articles/12430/figures |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Synapses and nuclei are connected by bidirectional communication mechanisms that enable information transfer encoded by macromolecules. Here, we identified RNF10 as a novel synaptonuclear protein messenger. RNF10 is activated by calcium signals at the postsynaptic compartment and elicits discrete changes at the transcriptional level. RNF10 is enriched at the excitatory synapse where it associates with the GluN2A subunit of NMDA receptors (NMDARs). Activation of synaptic GluN2A-containing NMDARs and induction of long term potentiation (LTP) lead to the translocation of RNF10 from dendritic segments and dendritic spines to the nucleus. In particular, we provide evidence for importin-dependent long-distance transport from synapto-dendritic compartments to the nucleus. Notably, RNF10 silencing prevents the maintenance of LTP as well as LTP-dependent structural modifications of dendritic spines.
1000 Sacherschließung
lokal dendritic spines
lokal importins
lokal rattus
lokal NMDA receptors
lokal synaptonuclear messengers
lokal neuroscience
lokal hippocampus
lokal rat
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/RGluYW1hcmNhLCBNYXJnYXJpdGEgQy4=|https://frl.publisso.de/adhoc/creator/R3V6emV0dGksIEZyYW5jZXNjYQ==|https://frl.publisso.de/adhoc/creator/S2FycG92YSwgQW5uYQ==|https://frl.publisso.de/adhoc/creator/TGltLCBEbWl0cnk=|https://frl.publisso.de/adhoc/creator/TWl0cm8sIE5pY28=|https://frl.publisso.de/adhoc/creator/TXVzYXJkbywgU3RlZmFubw==|https://frl.publisso.de/adhoc/creator/TWVsbG9uZSwgTWFudWVsYQ==|https://frl.publisso.de/adhoc/creator/TWFyY2VsbG8sIEVsZW5h|https://frl.publisso.de/adhoc/creator/U3RhbmljLCBKZW5uaWZlcg==|https://frl.publisso.de/adhoc/creator/U2FtYWRkYXIsIFRhbm1veQ==|https://frl.publisso.de/adhoc/creator/QnVyZ3Vpw6hyZSwgQWRlbGluZQ==|https://frl.publisso.de/adhoc/creator/Q2FsZGFyZWxsaSwgQW50b25pbw==|https://frl.publisso.de/adhoc/creator/R2VuYXp6YW5pLCBBcm1hbmRvIEEu|https://frl.publisso.de/adhoc/creator/UGVycm95LCBKdWxpZQ==|https://frl.publisso.de/adhoc/creator/RmFnbmksIExhdXJlbnQ=|https://frl.publisso.de/adhoc/creator/Q2Fub25pY28sIFBpZXIgTHVpZ2k=|https://frl.publisso.de/adhoc/creator/S3JldXR6LCBNaWNoYWVsIFIu|https://frl.publisso.de/adhoc/creator/R2FyZG9uaSwgRmFicml6aW8=|https://frl.publisso.de/adhoc/creator/RGkgTHVjYSwgTW9uaWNh
1000 Label
1000 Förderer
  1. European Commission |
  2. Fondazione CARIPLO (Cariplo Foundation, Italy) |
  3. Italian Ministry of Education, University and Research |
  4. Deutsche Forschungsgemeinschaft (DFG) |
  5. Center for behavioral brain sciences (CBBS) |
1000 Fördernummer
  1. #238608 (SYMBAD)
  2. 0795-2013
  3. RBAP11HSZS; ANR-13-JSV4-0005-01; 2010AHHP5H; 2010PWNJXK
  4. SFB779 TPB8; Kr1879/5-1/6-1
  5. -
1000 Förderprogramm
  1. FP7-PEOPLE-ITN-2008; FP7 MC-ITN NPlast
  2. -
  3. FIRB Project; SYNcity; PRIN2010-2011
  4. -
  5. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer European Commission |
    1000 Förderprogramm FP7-PEOPLE-ITN-2008; FP7 MC-ITN NPlast
    1000 Fördernummer #238608 (SYMBAD)
  2. 1000 joinedFunding-child
    1000 Förderer Fondazione CARIPLO (Cariplo Foundation, Italy) |
    1000 Förderprogramm -
    1000 Fördernummer 0795-2013
  3. 1000 joinedFunding-child
    1000 Förderer Italian Ministry of Education, University and Research |
    1000 Förderprogramm FIRB Project; SYNcity; PRIN2010-2011
    1000 Fördernummer RBAP11HSZS; ANR-13-JSV4-0005-01; 2010AHHP5H; 2010PWNJXK
  4. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft (DFG) |
    1000 Förderprogramm -
    1000 Fördernummer SFB779 TPB8; Kr1879/5-1/6-1
  5. 1000 joinedFunding-child
    1000 Förderer Center for behavioral brain sciences (CBBS) |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6404301.rdf
1000 Erstellt am 2017-09-04T17:14:29.411+0200
1000 Erstellt von 218
1000 beschreibt frl:6404301
1000 Bearbeitet von 288
1000 Zuletzt bearbeitet Tue Mar 30 10:57:44 CEST 2021
1000 Objekt bearb. Tue Mar 30 10:57:44 CEST 2021
1000 Vgl. frl:6404301
1000 Oai Id
  1. oai:frl.publisso.de:frl:6404301 |
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1000 Sichtbarkeit Daten public
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