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Transcriptional Control of Synaptic Plasticity by Transcription Factor NF-ýB.pdf 4,57MB
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1000 Titel
  • Transcriptional Control of Synaptic Plasticity by Transcription Factor NF-κB
1000 Autor/in
  1. Engelmann, Christian |
  2. Haenold, Ronny |
1000 Erscheinungsjahr 2016
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2016
1000 Erschienen in
1000 Quellenangabe
  • 2016:7027949
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2016
1000 Lizenz
1000 Verlagsversion
  • http://dx.doi.org/10.1155/2016/7027949 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4736603/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Activation of nuclear factor kappa B (NF-κB) transcription factors is required for the induction of synaptic plasticity and memory formation. All components of this signaling pathway are localized at synapses, and transcriptionally active NF-κB dimers move to the nucleus to translate synaptic signals into altered gene expression. Neuron-specific inhibition results in altered connectivity of excitatory and inhibitory synapses and functionally in selective learning deficits. Recent research on transgenic mice with impaired or hyperactivated NF-κB gave important insights into plasticity-related target gene expression that is regulated by NF-κB. In this minireview, we update the available data on the role of this transcription factor for learning and memory formation and comment on cross-sectional activation of NF-κB in the aged and diseased brain that may directly or indirectly affect κB-dependent transcription of synaptic genes.
1000 Fachgruppe
  1. Biologie |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/RW5nZWxtYW5uLCBDaHJpc3RpYW4=|https://frl.publisso.de/adhoc/creator/SGFlbm9sZCwgUm9ubnk=
1000 Förderer
  1. Leibniz Association, Germany |
  2. VELUX Foundation, Switzerland |
1000 Fördernummer
  1. -
  2. -
1000 Förderprogramm
  1. -
  2. -
1000 Dateien
  1. Transcriptional Control of Synaptic Plasticity by Transcription Factor NF-κB
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Leibniz Association, Germany |
    1000 Förderprogramm -
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer VELUX Foundation, Switzerland |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6404338.rdf
1000 Erstellt am 2017-09-08T14:20:38.169+0200
1000 Erstellt von 122
1000 beschreibt frl:6404338
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Wed Jun 27 11:26:55 CEST 2018
1000 Objekt bearb. Wed Jun 27 11:26:55 CEST 2018
1000 Vgl. frl:6404338
1000 Oai Id
  1. oai:frl.publisso.de:frl:6404338 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
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