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1000 Titel
  • Plasma proteomic analysis of active and torpid greater mouse-eared bats (Myotis myotis)
1000 Autor/in
  1. Hecht, Alexander M. |
  2. Braun, Beate C. |
  3. Krause, Eberhard |
  4. Voigt, Christian |
  5. Greenwood, Alex |
  6. Czirják, Gábor Árpád |
1000 Erscheinungsjahr 2015
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2015-11-20
1000 Erschienen in
1000 Quellenangabe
  • 5:16604
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2015
1000 Lizenz
1000 Verlagsversion
  • http://dx.doi.org/10.1038/srep16604 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4653738/ |
1000 Ergänzendes Material
  • https://www.nature.com/articles/srep16604#supplementary-information |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Hibernation is a physiological adaptation to overcome extreme environmental conditions. It is characterized by prolonged periods of torpor interrupted by temporary arousals during winter. During torpor, body functions are suppressed and restored rapidly to almost pre-hibernation levels during arousal. Although molecular studies have been performed on hibernating rodents and bears, it is unclear how generalizable the results are among hibernating species with different physiology such as bats. As targeted blood proteomic analysis are lacking in small hibernators, we investigated the general plasma proteomic profile of European Myotis myotis and hibernation associated changes between torpid and active individuals by two-dimensional gel electrophoresis. Results revealed an alternation of proteins involved in transport, fuel switching, innate immunity and blood coagulation between the two physiological states. The results suggest that metabolic changes during hibernation are associated with plasma proteomic changes. Further characterization of the proteomic plasma profile identified transport proteins, coagulation proteins and complement factors and detected a high abundance of alpha-fetoprotein. We were able to establish for the first time a basic myotid bat plasma proteomic profile and further demonstrated a modulated protein expression during torpor in Myotis myotis, indicating both novel physiological pathways in bats in general, and during hibernation in particular.
1000 Sacherschließung
lokal Molecular ecology
lokal Ecophysiology
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/SGVjaHQsIEFsZXhhbmRlciBNLg==|https://frl.publisso.de/adhoc/creator/QnJhdW4sIEJlYXRlIEMu|https://frl.publisso.de/adhoc/creator/S3JhdXNlLCBFYmVyaGFyZA==|http://orcid.org/0000-0002-0706-3974|https://orcid.org/0000-0002-8249-1565|https://orcid.org/0000-0001-9488-0069
1000 Label
1000 Förderer
  1. International Max Planck Research School for Infectious Diseases and Immunology |
  2. Leibniz Institute for Zoo and Wildlife Research, Berlin |
1000 Fördernummer
  1. -
  2. -
1000 Förderprogramm
  1. -
  2. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer International Max Planck Research School for Infectious Diseases and Immunology |
    1000 Förderprogramm -
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer Leibniz Institute for Zoo and Wildlife Research, Berlin |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6404462.rdf
1000 Erstellt am 2017-09-15T10:44:20.182+0200
1000 Erstellt von 122
1000 beschreibt frl:6404462
1000 Bearbeitet von 122
1000 Zuletzt bearbeitet 2021-04-20T09:24:11.478+0200
1000 Objekt bearb. Tue Apr 20 09:24:10 CEST 2021
1000 Vgl. frl:6404462
1000 Oai Id
  1. oai:frl.publisso.de:frl:6404462 |
1000 Sichtbarkeit Metadaten public
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