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1000 Titel
  • Biomarkers of Inflammation, Immunosuppression and Stress Are Revealed by Metabolomic Profiling of Tuberculosis Patients
1000 Autor/in
  1. Weiner, January |
  2. Parida, Shreemanta K. |
  3. Maertzdorf, Jeroen |
  4. Black, Gillian F. |
  5. Repsilber, Dirk |
  6. Telaar, Anna |
  7. Mohney, Robert P. |
  8. Arndt-Sullivan, Cordelia |
  9. Ganoza, Christian A. |
  10. Faé, Kellen C. |
  11. Walzl, Gerhard |
  12. Kaufmann, Stefan H. E. |
1000 Erscheinungsjahr 2012
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2012-07-23
1000 Erschienen in
1000 Quellenangabe
  • 7(7): e40221
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2012
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1371/journal.pone.0040221 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402490/ |
1000 Ergänzendes Material
  • http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0040221#s5 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Although tuberculosis (TB) causes more deaths than any other pathogen, most infected individuals harbor the pathogen without signs of disease. We explored the metabolome of >400 small molecules in serum of uninfected individuals, latently infected healthy individuals and patients with active TB. We identified changes in amino acid, lipid and nucleotide metabolism pathways, providing evidence for anti-inflammatory metabolomic changes in TB. Metabolic profiles indicate increased activity of indoleamine 2,3 dioxygenase 1 (IDO1), decreased phospholipase activity, increased abundance of adenosine metabolism products, as well as indicators of fibrotic lesions in active disease as compared to latent infection. Consistent with our predictions, we experimentally demonstrate TB-induced IDO1 activity. Furthermore, we demonstrate a link between metabolic profiles and cytokine signaling. Finally, we show that 20 metabolites are sufficient for robust discrimination of TB patients from healthy individuals. Our results provide specific insights into the biology of TB and pave the way for the rational development of metabolic biomarkers for TB.
1000 Sacherschließung
lokal Tuberculosis
lokal Cytokines
lokal Metabolites
lokal Mycobacterium tuberculosis
lokal Drug metabolism
lokal Xenobiotic metabolism
lokal Metabolic pathways
lokal Amino acid metabolism
1000 Fachgruppe
  1. Medizin |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/V2VpbmVyLCBKYW51YXJ5|https://frl.publisso.de/adhoc/creator/UGFyaWRhLCBTaHJlZW1hbnRhIEsu|https://frl.publisso.de/adhoc/creator/TWFlcnR6ZG9yZiwgSmVyb2Vu|https://frl.publisso.de/adhoc/creator/QmxhY2ssIEdpbGxpYW4gRi4=|https://frl.publisso.de/adhoc/creator/UmVwc2lsYmVyLCBEaXJr|https://frl.publisso.de/adhoc/creator/VGVsYWFyLCBBbm5h|https://frl.publisso.de/adhoc/creator/TW9obmV5LCBSb2JlcnQgUC4=|https://frl.publisso.de/adhoc/creator/QXJuZHQtU3VsbGl2YW4sIENvcmRlbGlh|https://frl.publisso.de/adhoc/creator/R2Fub3phLCBDaHJpc3RpYW4gQS4=|https://frl.publisso.de/adhoc/creator/RmHDqSwgS2VsbGVuIEMu|https://frl.publisso.de/adhoc/creator/V2FsemwsIEdlcmhhcmQ=|https://frl.publisso.de/adhoc/creator/S2F1Zm1hbm4sIFN0ZWZhbiBILiBFLg==
1000 Förderer
  1. Max Planck Society |
1000 Fördernummer
  1. -
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  1. floating grant
1000 Dateien
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    1000 Förderer Max Planck Society |
    1000 Förderprogramm floating grant
    1000 Fördernummer -
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1000 Erstellt am 2017-09-26T09:48:40.187+0200
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1000 Zuletzt bearbeitet Wed May 02 13:06:51 CEST 2018
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