WeightNameValue
1000 Titel
  • Nucleocytoplasmic Shuttling of the Golgi Phosphatidylinositol 4-Kinase Pik1 Is Regulated by 14-3-3 Proteins and Coordinates Golgi Function with Cell Growth
1000 Autor/in
  1. Demmel, Lars |
  2. Beck, Mike |
  3. Klose, Christian |
  4. Schlaitz, Anne-Lore |
  5. Gloor, Yvonne |
  6. Hsu, Peggy P. |
  7. Havlis, Jan |
  8. Shevchenko, Andrej |
  9. Krause, Eberhard |
  10. Kalaidzidis, Yannis |
  11. Walch-Solimena, Christiane |
1000 Erscheinungsjahr 2008
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2008-01-02
1000 Erschienen in
1000 Quellenangabe
  • 19(3): 1046-1061
1000 FRL-Sammlung
1000 Verlagsversion
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2262966/ |
  • http://dx.doi.org/10.1091/mbc.E07-02-0134 |
1000 Ergänzendes Material
  • http://www.molbiolcell.org/content/19/3/1046/suppl/DC1 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • The yeast phosphatidylinositol 4-kinase Pik1p is essential for proliferation, and it controls Golgi homeostasis and transport of newly synthesized proteins from this compartment. At the Golgi, phosphatidylinositol 4-phosphate recruits multiple cytosolic effectors involved in formation of post-Golgi transport vesicles. A second pool of catalytically active Pik1p localizes to the nucleus. The physiological significance and regulation of this dual localization of the lipid kinase remains unknown. Here, we show that Pik1p binds to the redundant 14-3-3 proteins Bmh1p and Bmh2p. We provide evidence that nucleocytoplasmic shuttling of Pik1p involves phosphorylation and that 14-3-3 proteins bind Pik1p in the cytoplasm. Nutrient deprivation results in relocation of Pik1p from the Golgi to the nucleus and increases the amount of Pik1p–14-3-3 complex, a process reversed upon restored nutrient supply. These data suggest a role of Pik1p nucleocytoplasmic shuttling in coordination of biosynthetic transport from the Golgi with nutrient signaling.
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/RGVtbWVsLCBMYXJz|https://frl.publisso.de/adhoc/creator/QmVjaywgTWlrZQ==|https://frl.publisso.de/adhoc/creator/S2xvc2UsIENocmlzdGlhbg==|https://frl.publisso.de/adhoc/creator/U2NobGFpdHosIEFubmUtTG9yZQ==|https://frl.publisso.de/adhoc/creator/R2xvb3IsIFl2b25uZQ==|https://frl.publisso.de/adhoc/creator/SHN1LCBQZWdneSBQLg==|https://frl.publisso.de/adhoc/creator/SGF2bGlzLCBKYW4=|https://frl.publisso.de/adhoc/creator/U2hldmNoZW5rbywgQW5kcmVq|https://frl.publisso.de/adhoc/creator/S3JhdXNlLCBFYmVyaGFyZA==|https://frl.publisso.de/adhoc/creator/S2FsYWlkemlkaXMsIFlhbm5pcw==|https://frl.publisso.de/adhoc/creator/V2FsY2gtU29saW1lbmEsIENocmlzdGlhbmU=
1000 Label
1000 Förderer
  1. Max Planck Society |
1000 Fördernummer
  1. -
1000 Förderprogramm
  1. -
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Max Planck Society |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6404827.rdf
1000 Erstellt am 2017-10-05T12:35:48.562+0200
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1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Thu Aug 18 07:51:45 CEST 2022
1000 Objekt bearb. Fri Jun 03 17:30:43 CEST 2022
1000 Vgl. frl:6404827
1000 Oai Id
  1. oai:frl.publisso.de:frl:6404827 |
1000 Sichtbarkeit Metadaten public
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