Clinical Relevance of Biomarkers of Oxidative Stress

  1. Frijhoff, Jeroen
  2. Winyard, Paul G.
  3. Zarkovic, Neven
  4. Davies, Sean S.
  5. Stocker, Roland
  6. Cheng, David
  7. Knight, Annie R.
  8. Taylor, Emma Louise
  9. Oettrich, Jeannette
  10. Ruskovska, Tatjana
  11. Gasparovic, Ana Cipak
  12. Cuadrado, Antonio
  13. Poulsen, Henrik Enghusen
  14. Schmidt, Harald H.H.W.
  15. Ghezzi, Pietro
  16. Weber, Daniela ORCID logo
  17. Grune, Tilman ORCID logo

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WeightNameValue
1000 Titel
  • Clinical Relevance of Biomarkers of Oxidative Stress
1000 Autor/in
  1. Frijhoff, Jeroen |
  2. Winyard, Paul G. |
  3. Zarkovic, Neven |
  4. Davies, Sean S. |
  5. Stocker, Roland |
  6. Cheng, David |
  7. Knight, Annie R. |
  8. Taylor, Emma Louise |
  9. Oettrich, Jeannette |
  10. Ruskovska, Tatjana |
  11. Gasparovic, Ana Cipak |
  12. Cuadrado, Antonio |
  13. Poulsen, Henrik Enghusen |
  14. Schmidt, Harald H.H.W. |
  15. Ghezzi, Pietro |
  16. Weber, Daniela |
  17. Grune, Tilman |
1000 Erscheinungsjahr 2015
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2015-10-26
1000 Erschienen in
1000 Quellenangabe
  • 23(14): 1144-1170
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2015
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1089/ars.2015.6317 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4657513/ |
1000 Ergänzendes Material
  • http://online.liebertpub.com/doi/suppl/10.1089/ars.2015.6317/suppl_file/Supp_Data.pdf |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • SIGNIFICANCE: Oxidative stress is considered to be an important component of various diseases. A vast number of methods have been developed and used in virtually all diseases to measure the extent and nature of oxidative stress, ranging from oxidation of DNA to proteins, lipids, and free amino acids. RECENT ADVANCES: An increased understanding of the biology behind diseases and redox biology has led to more specific and sensitive tools to measure oxidative stress markers, which are very diverse and sometimes very low in abundance. CRITICAL ISSUES: The literature is very heterogeneous. It is often difficult to draw general conclusions on the significance of oxidative stress biomarkers, as only in a limited proportion of diseases have a range of different biomarkers been used, and different biomarkers have been used to study different diseases. In addition, biomarkers are often measured using nonspecific methods, while specific methodologies are often too sophisticated or laborious for routine clinical use. FUTURE DIRECTIONS: Several markers of oxidative stress still represent a viable biomarker opportunity for clinical use. However, positive findings with currently used biomarkers still need to be validated in larger sample sizes and compared with current clinical standards to establish them as clinical diagnostics. It is important to realize that oxidative stress is a nuanced phenomenon that is difficult to characterize, and one biomarker is not necessarily better than others. The vast diversity in oxidative stress between diseases and conditions has to be taken into account when selecting the most appropriate biomarker. Antioxid. Redox Signal. 23, 1144–1170.
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
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1000 Label
1000 Förderer
  1. European Cooperation in Science and Technology |
  2. Peptide Research Network of Excellence |
  3. European Cross-border Cooperation |
  4. Europäischer Fonds für regionale Entwicklung (ERDF) |
  5. Toyota foundation, Denmark |
  6. National Health and Medical Research Council |
  7. National Institutes of Health |
  8. Defence Science and Technology Laboratory, United Kingdom |
1000 Fördernummer
  1. BM1203/EU-ROS
  2. -
  3. -
  4. -
  5. -
  6. 1020776; 1060804
  7. HL116263
  8. -
1000 Förderprogramm
  1. COST Action
  2. -
  3. Programme INTERREG IV A France (Channel)-England
  4. -
  5. -
  6. Senior Principal Research Fellowship
  7. -
  8. grant
1000 Dateien
  1. Clinical Relevance of Biomarkers of Oxidative Stress
    Clinical Relevance of Biomarkers of Oxidative Stress
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer European Cooperation in Science and Technology |
    1000 Förderprogramm COST Action
    1000 Fördernummer BM1203/EU-ROS
  2. 1000 joinedFunding-child
    1000 Förderer Peptide Research Network of Excellence |
    1000 Förderprogramm -
    1000 Fördernummer -
  3. 1000 joinedFunding-child
    1000 Förderer European Cross-border Cooperation |
    1000 Förderprogramm Programme INTERREG IV A France (Channel)-England
    1000 Fördernummer -
  4. 1000 joinedFunding-child
    1000 Förderer Europäischer Fonds für regionale Entwicklung (ERDF) |
    1000 Förderprogramm -
    1000 Fördernummer -
  5. 1000 joinedFunding-child
    1000 Förderer Toyota foundation, Denmark |
    1000 Förderprogramm -
    1000 Fördernummer -
  6. 1000 joinedFunding-child
    1000 Förderer National Health and Medical Research Council |
    1000 Förderprogramm Senior Principal Research Fellowship
    1000 Fördernummer 1020776; 1060804
  7. 1000 joinedFunding-child
    1000 Förderer National Institutes of Health |
    1000 Förderprogramm -
    1000 Fördernummer HL116263
  8. 1000 joinedFunding-child
    1000 Förderer Defence Science and Technology Laboratory, United Kingdom |
    1000 Förderprogramm grant
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6404884.rdf
1000 Erstellt am 2017-10-09T15:48:40.642+0200
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1000 Zuletzt bearbeitet 2021-03-04T07:50:55.331+0100
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1000 Oai Id
  1. oai:frl.publisso.de:frl:6404884 |
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