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1000 Titel
  • Aeromonas salmonicida Infection Only Moderately Regulates Expression of Factors Contributing to Toll-Like Receptor Signaling but Massively Activates the Cellular and Humoral Branches of Innate Immunity in Rainbow Trout (Oncorhynchus mykiss)
1000 Autor/in
  1. Brietzke, Andreas |
  2. Korytář, Tomáš |
  3. Jaros, Joanna |
  4. Köllner, Bernd |
  5. Goldammer, Tom |
  6. Seyfert, Hans-Martin |
  7. Rebl, Alexander |
1000 Erscheinungsjahr 2015
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2015-07-22
1000 Erschienen in
1000 Quellenangabe
  • 2015: 901015
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2015
1000 Lizenz
1000 Verlagsversion
  • http://dx.doi.org/10.1155/2015/901015 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4525466/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Toll-like receptors (TLRs) are known to detect a defined spectrum of microbial structures. However, the knowledge about the specificity of teleost Tlr factors for distinct pathogens is limited so far. We measured baseline expression profiles of 18 tlr genes and associated signaling factors in four immune-relevant tissues of rainbow trout Oncorhynchus mykiss. Intraperitoneal injection of a lethal dose of Aeromonas salmonicida subsp. salmonicida induced highly increased levels of cytokine mRNAs during a 72-hour postinfection (hpi) period. In contrast, only the fish-specific tlr22a2 and the downstream factor irak1 featured clearly increased transcript levels, while the mRNA concentrations of many other tlr genes decreased. Flow cytometry quantified cell trafficking after infection indicating a dramatic influx of myeloid cells into the peritoneum and a belated low level immigration of lymphoid cells. T and B lymphocytes were differentiated with RT-qPCR revealing that B lymphocytes emigrated from and T lymphocytes immigrated into head kidney. In conclusion, no specific TLR can be singled out as a dominant receptor for A. salmonicida. The recruitment of cellular factors of innate immunity rather than induced expression of pathogen receptors is hence of key importance for mounting a first immune defense against invading A. salmonicida.
1000 Fachgruppe
  1. Biologie |
  2. Agrarwissenschaften |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/QnJpZXR6a2UsIEFuZHJlYXM=|https://frl.publisso.de/adhoc/creator/S29yeXTDocWZLCBUb23DocWh|https://frl.publisso.de/adhoc/creator/SmFyb3MsIEpvYW5uYQ==|https://frl.publisso.de/adhoc/creator/S8O2bGxuZXIsIEJlcm5k|http://orcid.org/0000-0003-1215-5504|https://frl.publisso.de/adhoc/creator/U2V5ZmVydCwgSGFucy1NYXJ0aW4=|http://orcid.org/0000-0002-2918-7433
1000 Label
1000 Förderer
  1. German Research Foundation (DFG) |
1000 Fördernummer
  1. SE 326/16-1
1000 Förderprogramm
  1. DFG-Grant
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer German Research Foundation (DFG) |
    1000 Förderprogramm DFG-Grant
    1000 Fördernummer SE 326/16-1
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6405100.rdf
1000 Erstellt am 2017-10-20T15:22:32.380+0200
1000 Erstellt von 218
1000 beschreibt frl:6405100
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Thu Jan 30 20:51:29 CET 2020
1000 Objekt bearb. Tue Dec 04 11:24:31 CET 2018
1000 Vgl. frl:6405100
1000 Oai Id
  1. oai:frl.publisso.de:frl:6405100 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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