foraita1.pdf 441,41KB
1000 Titel
  • The influence of aerobic fitness on obesity and its parent-offspring correlations in a cross-sectional study among German families
1000 Autor/in
  1. Foraita, Ronja |
  2. Brandes, Mirko |
  3. Günther, Frauke |
  4. Bammann, Karin |
  5. Pigeot, Iris |
  6. Ahrens, Wolfgang |
1000 Erscheinungsjahr 2015
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2015-07-11
1000 Erschienen in
1000 Quellenangabe
  • 15:638
1000 Sammlung
1000 Copyrightjahr
  • 2015
1000 Lizenz
1000 Verlagsversion
  • |
  • |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • BACKGROUND: Overweight/obesity is an important public health burden worldwide, increasing the risk for the development of cardiovascular diseases or the metabolic syndrome. This risk may be reduced by a good aerobic fitness (AF) that can be improved by physical activity but is also influenced by genetic factors. The aim of this study was to test for familial aggregation of AF measured by maximal oxygen uptake (VO(2max)) and to estimate its heritability. Furthermore, an exploratory analysis of the association between overweight/obesity and AF was performed. In contrast to previous studies, all analyses were adjusted for additional environmental and behavioral factors, in particular for objectively measured physical activity (PA) in addition to body mass index (BMI). METHODS: 79 families (157 parents, 132 children) performed a maximum exercise test (spiroergometry) to assess maximum oxygen uptake. PA was measured by accelerometry. Familial aggregation of AF was determined using a two-step design: AF was adjusted for age, sex and age*sex using linear regression. Afterwards, the residuals were used to determine the intraclass correlation coefficient (ICC) by ANOVA. Heritability and associations were estimated by generalized linear mixed models. RESULTS: Familial aggregation of AF (ICC = 0.22, p < 0.001) was significant but decreased when adjusted for PA or BMI. Its heritability was estimated as 40 % (adjusted for PA) using the mid-parent-offspring design. Relative to the middle quintile of AF residuals, the odds of being overweight/obese were three- to tenfold reduced in the upper quintile (adjusted for age, sex, age*sex, PA). CONCLUSIONS: AF clustered in families after controlling for PA, BMI and parental smoking. Heritability was stronger for mother-child pairs as compared to father-child pairs after controlling for PA and BMI. Above average AF was negatively associated with overweight/obesity.
1000 Freie Schlagwörter
  • IDEFICS study
  • physical activity
  • cardio-respiratory fitness
  • familial aggregation
  • heritability
1000 Fachgruppe
  1. Medizin |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
1000 Förderer
  1. Federal Ministry of Education and Research
1000 Fördernummer
  1. DLR 01GI0822
1000 Förderprogramm
  1. Competence Network of Obesity
1000 Dateien
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6405197.rdf
1000 Erstellt am 2017-10-26T10:16:01.943+0200
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