WeightNameValue
1000 Titel
  • Ca2+ permeation in cyclic nucleotide‐gated channels
1000 Autor/in
  1. Dzeja, Claudia |
  2. Hagen, Volker |
  3. Kaupp, U.Benjamin |
  4. Frings, Stephan |
1000 Erscheinungsjahr 1999
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 1999-01-04
1000 Erschienen in
1000 Quellenangabe
  • 18(1): 131-144
1000 FRL-Sammlung
1000 Verlagsversion
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1171109/ |
  • http://doi.org/10.1093/emboj/18.1.131 |
1000 Ergänzendes Material
  • http://emboj.embopress.org/content/18/1/131.figures-only |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Cyclic nucleotide‐gated (CNG) channels conduct Na+, K+ and Ca2+ currents under the control of cGMP and cAMP. Activation of CNG channels leads to depolarization of the membrane voltage and to a concomitant increase of the cytosolic Ca2+ concentration. Several polypeptides were identified that constitute principal and modulatory subunits of CNG channels in both neurons and non‐excitable cells, co‐assembling to form a variety of heteromeric proteins with distinct biophysical properties. Since the contribution of each channel type to Ca2+ signaling depends on its specific Ca2+ conductance, it is necessary to analyze Ca2+ permeation for each individual channel type. We have analyzed Ca2+ permeation in all principal subunits of vertebrates and for a principal subunit from Drosophila melanogaster. We measured the fractional Ca2+ current over the physiological range of Ca2+ concentrations and found that Ca2+ permeation is determined by subunit composition and modulated by membrane voltage and extracellular pH. Ca2+ permeation is controlled by the Ca2+‐binding affinity of the intrapore cation‐binding site, which varies profoundly between members of the CNG channel family, and gives rise to a surprising diversity in the ability to generate Ca2+ signals.
1000 Sacherschließung
lokal Calcium Permeation
lokal Signal Transduction
lokal Cyclic Nucleotide
lokal Ion Channel
lokal Olfactory Sensory Neuron
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/RHplamEsIENsYXVkaWE=|https://frl.publisso.de/adhoc/creator/SGFnZW4sIFZvbGtlcg==|https://frl.publisso.de/adhoc/creator/S2F1cHAsIFUuQmVuamFtaW4=|https://frl.publisso.de/adhoc/creator/RnJpbmdzLCBTdGVwaGFu
1000 Label
1000 Förderer
  1. Studienstiftung des Deutschen Volkes |
  2. Deutsche Forschungsgemeinschaft |
1000 Fördernummer
  1. -
  2. -
1000 Förderprogramm
  1. -
  2. FR 937
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Studienstiftung des Deutschen Volkes |
    1000 Förderprogramm -
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft |
    1000 Förderprogramm FR 937
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6405321.rdf
1000 Erstellt am 2017-11-07T15:23:51.983+0100
1000 Erstellt von 25
1000 beschreibt frl:6405321
1000 Bearbeitet von 288
1000 Zuletzt bearbeitet 2022-08-18T07:49:13.029+0200
1000 Objekt bearb. Wed Mar 31 07:44:18 CEST 2021
1000 Vgl. frl:6405321
1000 Oai Id
  1. oai:frl.publisso.de:frl:6405321 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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