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1000 Titel
  • Irisin Is Elevated in Skeletal Muscle and Serum of Mice Immediately after Acute Exercise
1000 Autor/in
  1. Brenmoehl, Julia |
  2. Komolka, Katrin |
  3. Schering, Lisa |
  4. Langhammer, Martina |
  5. Albrecht, Elke |
  6. Hoeflich, Andreas |
  7. Maak, Steffen |
1000 Erscheinungsjahr 2014
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2014-03-11
1000 Erschienen in
1000 Quellenangabe
  • 10(3): 338-349
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2014
1000 Lizenz
1000 Verlagsversion
  • https://dx.doi.org/10.7150/ijbs.7972 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3957089/ |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Recent findings regarding the response of fibronectin type III domain-containing protein 5 (Fndc5) and irisin to exercise are partly controversial. While the 25 kDa form of Fndc5 can be observed in muscle and serum of different species, the ~12 kDa irisin band was not detectable up to now. The present study aimed to clarify whether irisin exists in its theoretical size of ~12 kDa in mice and if it is affected by exercise. Male mice were randomly assigned to a sedentary control group (CO), a group with free access to running wheels (RW), and a treadmill group (TM). Blood and leg muscles were collected to investigate the regulatory cascade including peroxisome proliferator-activated receptor gamma co-activator 1-alpha (Ppargc1a) and Fndc5. In western blot analysis, antibodies were used capable of differentiation between full-length Fndc5 and irisin. This enabled us to demonstrate that irisin exists in muscle and serum of mice independent of exercise and that it is increased immediately after acute exercise. Different transcripts of Ppargc1a mRNA, but not Fndc5 mRNA, were up-regulated in the TM group. Furthermore, neither Fndc5 (25 kDa) nor Ppargc1a protein was elevated in muscle tissue. The Ppargc1a-Fndc5/irisin pathway did not clearly respond to mild exercise in the RW group. Our results provide evidence for the existence of irisin and for its immediate response to acute exercise in mice.
1000 Sacherschließung
lokal Fndc5
lokal endurance exercise
lokal myokine
lokal Ppargc1a
lokal irisin
1000 Fachgruppe
  1. Biologie |
  2. Agrarwissenschaften |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/QnJlbm1vZWhsLCBKdWxpYQ==|https://frl.publisso.de/adhoc/creator/S29tb2xrYSwgS2F0cmlu|https://frl.publisso.de/adhoc/creator/U2NoZXJpbmcsIExpc2E=|https://frl.publisso.de/adhoc/creator/TGFuZ2hhbW1lciwgTWFydGluYQ==|http://orcid.org/0000-0001-5974-1514|http://orcid.org/0000-0003-2018-2836|http://orcid.org/0000-0003-2681-1496
1000 Label
1000 Förderer
  1. Leibniz Association |
  2. Deutsche Forschungsgemeinschaft (DFG) |
1000 Fördernummer
  1. SAW-2013-FBN-3
  2. DFG H0 2003/6-1
1000 Förderprogramm
  1. -
  2. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Leibniz Association |
    1000 Förderprogramm -
    1000 Fördernummer SAW-2013-FBN-3
  2. 1000 joinedFunding-child
    1000 Förderer Deutsche Forschungsgemeinschaft (DFG) |
    1000 Förderprogramm -
    1000 Fördernummer DFG H0 2003/6-1
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6405477.rdf
1000 Erstellt am 2017-11-23T18:19:21.585+0100
1000 Erstellt von 218
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1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Thu Jan 30 20:56:13 CET 2020
1000 Objekt bearb. Mon May 28 10:25:01 CEST 2018
1000 Vgl. frl:6405477
1000 Oai Id
  1. oai:frl.publisso.de:frl:6405477 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
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