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1000 Titel
  • Wnt activity and basal niche position sensitize intestinal stem and progenitor cells to DNA damage
1000 Autor/in
  1. Tao, Si |
  2. Tang, Duozhuang |
  3. Morita, Yohei |
  4. Sperka, Tobias |
  5. Omrani, Omid |
  6. Lechel, André |
  7. Sakk, Vadim |
  8. Kraus, Johann |
  9. Kestler, Hans A. |
  10. Kühl, Michael |
  11. Rudolph, Karl Lenhard |
1000 Erscheinungsjahr 2015
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2015-01-21
1000 Erschienen in
1000 Quellenangabe
  • 34(5): 624-640
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2015
1000 Lizenz
1000 Verlagsversion
  • https://dx.doi.org/10.15252/embj.201490700 |
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4365032/ |
1000 Ergänzendes Material
  • http://emboj.embopress.org/content/34/5/624#sec-28 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Aging and carcinogenesis coincide with the accumulation of DNA damage and mutations in stem and progenitor cells. Molecular mechanisms that influence responses of stem and progenitor cells to DNA damage remain to be delineated. Here, we show that niche positioning and Wnt signaling activity modulate the sensitivity of intestinal stem and progenitor cells (ISPCs) to DNA damage. ISPCs at the crypt bottom with high Wnt/β‐catenin activity are more sensitive to DNA damage compared to ISPCs in position 4 with low Wnt activity. These differences are not induced by differences in cell cycle activity but relate to DNA damage‐dependent activation of Wnt signaling, which in turn amplifies DNA damage checkpoint activation. The study shows that instructed enhancement of Wnt signaling increases radio‐sensitivity of ISPCs, while inhibition of Wnt signaling decreases it. These results provide a proof of concept that cell intrinsic levels of Wnt signaling modulate the sensitivity of ISPCs to DNA damage and heterogeneity in Wnt activation in the stem cell niche contributes to the selection of ISPCs in the context of DNA damage.
1000 Sacherschließung
lokal intestinal progenitor cells
lokal DNA damage
lokal intestinal stem cells
lokal telomeres
lokal Wnt
1000 Fachgruppe
  1. Biologie |
  2. Medizin |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/VGFvLCBTaQ==|https://frl.publisso.de/adhoc/creator/VGFuZyzCoER1b3podWFuZw==|https://frl.publisso.de/adhoc/creator/TW9yaXRhLMKgWW9oZWk=|https://frl.publisso.de/adhoc/creator/U3BlcmthLCBUb2JpYXM=|https://frl.publisso.de/adhoc/creator/T21yYW5pLCBPbWlk|https://frl.publisso.de/adhoc/creator/TGVjaGVsLCBBbmRyw6k=|https://frl.publisso.de/adhoc/creator/U2FraywgVmFkaW0=|https://frl.publisso.de/adhoc/creator/S3JhdXMsIEpvaGFubg==|https://frl.publisso.de/adhoc/creator/S2VzdGxlciwgSGFucyBBLg==|https://frl.publisso.de/adhoc/creator/S8O8aGwsIE1pY2hhZWw=|http://orcid.org/0000-0002-4839-2862
1000 Label
1000 Förderer
  1. German Federal Ministry of Education and Research (BMBF) |
  2. European Union |
  3. International Graduate School in Molecular Medicine, Ulm |
  4. Excellence Initiative of the German Federal and State Governments |
1000 Fördernummer
  1. -
  2. 323136
  3. -
  4. GSC270
1000 Förderprogramm
  1. joint research project: SyStaR
  2. Stem Cell Geronto Genes
  3. -
  4. -
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer German Federal Ministry of Education and Research (BMBF) |
    1000 Förderprogramm joint research project: SyStaR
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer European Union |
    1000 Förderprogramm Stem Cell Geronto Genes
    1000 Fördernummer 323136
  3. 1000 joinedFunding-child
    1000 Förderer International Graduate School in Molecular Medicine, Ulm |
    1000 Förderprogramm -
    1000 Fördernummer -
  4. 1000 joinedFunding-child
    1000 Förderer Excellence Initiative of the German Federal and State Governments |
    1000 Förderprogramm -
    1000 Fördernummer GSC270
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6405481.rdf
1000 Erstellt am 2017-11-23T19:00:25.423+0100
1000 Erstellt von 218
1000 beschreibt frl:6405481
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Thu Jan 30 23:34:39 CET 2020
1000 Objekt bearb. Thu Jun 28 11:18:11 CEST 2018
1000 Vgl. frl:6405481
1000 Oai Id
  1. oai:frl.publisso.de:frl:6405481 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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