WeightNameValue
1000 Titel
  • Fast neurotransmitter release regulated by the endocytic scaffold intersectin
1000 Autor/in
  1. Sakaba, Takeshi |
  2. Kononenko, Natalia L. |
  3. Bacetic, Jelena |
  4. Pechstein, Arndt |
  5. Schmoranzer, Jan |
  6. Yao, Lijun |
  7. Barth, Holger |
  8. Shupliakov, Oleg |
  9. Kobler, Oliver |
  10. Aktories, Klaus |
  11. Haucke, Volker |
1000 Erscheinungsjahr 2013
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2013-04-30
1000 Erschienen in
1000 Quellenangabe
  • 110(20): 8266–8271
1000 FRL-Sammlung
1000 Verlagsversion
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657817/ |
  • http://doi.org/10.1073/pnas.1219234110 |
1000 Ergänzendes Material
  • http://www.pnas.org/lookup/suppl/doi:10.1073/pnas.1219234110/-/DCSupplemental |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Sustained fast neurotransmission requires the rapid replenishment of release-ready synaptic vesicles (SVs) at presynaptic active zones. Although the machineries for exocytic fusion and for subsequent endocytic membrane retrieval have been well characterized, little is known about the mechanisms underlying the rapid recruitment of SVs to release sites. Here we show that the Down syndrome-associated endocytic scaffold protein intersectin 1 is a crucial factor for the recruitment of release-ready SVs. Genetic deletion of intersectin 1 expression or acute interference with intersectin function inhibited the replenishment of release-ready vesicles, resulting in short-term depression, without significantly affecting the rate of endocytic membrane retrieval. Acute perturbation experiments suggest that intersectin-mediated vesicle replenishment involves the association of intersectin with the fissioning enzyme dynamin and with the actin regulatory GTPase CDC42. Our data indicate a role for the endocytic scaffold intersectin in fast neurotransmitter release, which may be of prime importance for information processing in the brain.
1000 Sacherschließung
lokal synaptic transmission
lokal endocytosis
lokal synaptic vesicle recruitment
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/U2FrYWJhLCBUYWtlc2hp|https://frl.publisso.de/adhoc/creator/S29ub25lbmtvLCBOYXRhbGlhIEwu|https://frl.publisso.de/adhoc/creator/QmFjZXRpYywgSmVsZW5h|https://frl.publisso.de/adhoc/creator/UGVjaHN0ZWluLCBBcm5kdA==|https://frl.publisso.de/adhoc/creator/U2NobW9yYW56ZXIsIEphbg==|https://frl.publisso.de/adhoc/creator/WWFvLCBMaWp1bg==|https://frl.publisso.de/adhoc/creator/QmFydGgsIEhvbGdlcg==|https://frl.publisso.de/adhoc/creator/U2h1cGxpYWtvdiwgT2xlZw==|https://frl.publisso.de/adhoc/creator/S29ibGVyLCBPbGl2ZXI=|https://frl.publisso.de/adhoc/creator/QWt0b3JpZXMsIEtsYXVz|http://orcid.org/0000-0003-3119-6993
1000 Label
1000 Förderer
  1. Japan Society for the Promotion of Science |
  2. Toray Science Foundation |
  3. Uehara Foundation |
  4. Swedish Research Council |
  5. German Research Foundation (DFG) |
1000 Fördernummer
  1. 24300144; 24650218
  2. -
  3. -
  4. -
  5. EXC 257; SFB958/A01; SFB958/Z02
1000 Förderprogramm
  1. KAKENHI; Core-to-Core Program A
  2. -
  3. -
  4. -
  5. -
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer Japan Society for the Promotion of Science |
    1000 Förderprogramm KAKENHI; Core-to-Core Program A
    1000 Fördernummer 24300144; 24650218
  2. 1000 joinedFunding-child
    1000 Förderer Toray Science Foundation |
    1000 Förderprogramm -
    1000 Fördernummer -
  3. 1000 joinedFunding-child
    1000 Förderer Uehara Foundation |
    1000 Förderprogramm -
    1000 Fördernummer -
  4. 1000 joinedFunding-child
    1000 Förderer Swedish Research Council |
    1000 Förderprogramm -
    1000 Fördernummer -
  5. 1000 joinedFunding-child
    1000 Förderer German Research Foundation (DFG) |
    1000 Förderprogramm -
    1000 Fördernummer EXC 257; SFB958/A01; SFB958/Z02
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6405607.rdf
1000 Erstellt am 2017-12-01T11:15:09.550+0100
1000 Erstellt von 25
1000 beschreibt frl:6405607
1000 Bearbeitet von 288
1000 Zuletzt bearbeitet 2021-03-04T08:06:07.894+0100
1000 Objekt bearb. Thu Mar 04 08:06:07 CET 2021
1000 Vgl. frl:6405607
1000 Oai Id
  1. oai:frl.publisso.de:frl:6405607 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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