WeightNameValue
1000 Titel
  • Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis
1000 Autor/in
  1. Hamidi, Tewfik |
  2. Algül, Hana |
  3. Cano, Carla Eliana |
  4. Sandi, Maria José |
  5. Molejon, Maria Inés |
  6. Riemann, Marc |
  7. Calvo, Ezequiel Luis |
  8. Lomberk, Gwen |
  9. Dagorn, Jean-Charles |
  10. Weih, Falk |
  11. Urrutia, Raul |
  12. Schmid, Roland Michael |
  13. Iovanna, Juan Lucio |
1000 Erscheinungsjahr 2012
1000 LeibnizOpen
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2012-05-08
1000 Erschienen in
1000 Quellenangabe
  • 122(6): 2092-2103
1000 FRL-Sammlung
1000 Verlagsversion
  • http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366404/ |
  • http://doi.org/10.1172/JCI60144 |
1000 Ergänzendes Material
  • https://www.jci.org/articles/view/60144#sd |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Pancreatic ductal adenocarcinoma (PDAC) has the lowest survival rate of all cancers and shows remarkable resistance to cell stress. Nuclear protein 1 (Nupr1), which mediates stress response in the pancreas, is frequently upregulated in pancreatic cancer. Here, we report that Nupr1 plays an essential role in pancreatic tumorigenesis. In a mouse model of pancreatic cancer with constitutively expressed oncogenic KrasG12D, we found that loss of Nupr1 protected from the development of pancreatic intraepithelial neoplasias (PanINs). Further, in cultured pancreatic cells, nutrient deprivation activated Nupr1 expression, which we found to be required for cell survival. We found that Nupr1 protected cells from stress-induced death by inhibiting apoptosis through a pathway dependent on transcription factor RelB and immediate early response 3 (IER3). NUPR1, RELB, and IER3 proteins were coexpressed in mouse PanINs from KrasG12D-expressing pancreas. Moreover, pancreas-specific deletion of Relb in a KrasG12D background resulted in delayed in PanIN development associated with a lack of IER3 expression. Thus, efficient PanIN formation was dependent on the expression of Nupr1 and Relb, with likely involvement of IER3. Finally, in patients with PDAC, expression of NUPR1, RELB, and IER3 was significantly correlated with a poor prognosis. Cumulatively, these results reveal a NUPR1/RELB/IER3 stress-related pathway that is required for oncogenic KrasG12D-dependent transformation of the pancreas.
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/SGFtaWRpLCBUZXdmaWs=|https://frl.publisso.de/adhoc/creator/QWxnw7xsLCBIYW5h|https://frl.publisso.de/adhoc/creator/Q2FubywgQ2FybGEgRWxpYW5h|https://frl.publisso.de/adhoc/creator/U2FuZGksIE1hcmlhIEpvc8Op|https://frl.publisso.de/adhoc/creator/TW9sZWpvbiwgTWFyaWEgSW7DqXM=|https://frl.publisso.de/adhoc/creator/UmllbWFubiwgTWFyYw==|https://frl.publisso.de/adhoc/creator/Q2Fsdm8sIEV6ZXF1aWVsIEx1aXM=|https://frl.publisso.de/adhoc/creator/TG9tYmVyaywgR3dlbg==|https://frl.publisso.de/adhoc/creator/RGFnb3JuLCBKZWFuLUNoYXJsZXM=|https://frl.publisso.de/adhoc/creator/V2VpaCwgRmFsaw==|https://frl.publisso.de/adhoc/creator/VXJydXRpYSwgUmF1bA==|https://frl.publisso.de/adhoc/creator/U2NobWlkLCBSb2xhbmQgTWljaGFlbA==|https://frl.publisso.de/adhoc/creator/SW92YW5uYSwgSnVhbiBMdWNpbw==
1000 Label
1000 Förderer
  1. La Ligue contre le Cancer |
  2. Institut national du cancer |
  3. INSERM |
  4. German Cancer Aid |
  5. German Federal Ministry of Education and Research |
  6. Lustgarten Foundation |
  7. German Research Foundation |
  8. NIH |
  9. l’Association pour la Recherche sur le Cancer |
  10. Fraternal Order of Eagles for Cancer Research |
1000 Fördernummer
  1. -
  2. INCa
  3. -
  4. 107195
  5. 01GS08115
  6. RFP05-14; RFP06-12
  7. SI 1549/1-1
  8. DK52913
  9. -
  10. -
1000 Förderprogramm
  1. -
  2. -
  3. -
  4. -
  5. -
  6. -
  7. -
  8. -
  9. -
  10. -
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer La Ligue contre le Cancer |
    1000 Förderprogramm -
    1000 Fördernummer -
  2. 1000 joinedFunding-child
    1000 Förderer Institut national du cancer |
    1000 Förderprogramm -
    1000 Fördernummer INCa
  3. 1000 joinedFunding-child
    1000 Förderer INSERM |
    1000 Förderprogramm -
    1000 Fördernummer -
  4. 1000 joinedFunding-child
    1000 Förderer German Cancer Aid |
    1000 Förderprogramm -
    1000 Fördernummer 107195
  5. 1000 joinedFunding-child
    1000 Förderer German Federal Ministry of Education and Research |
    1000 Förderprogramm -
    1000 Fördernummer 01GS08115
  6. 1000 joinedFunding-child
    1000 Förderer Lustgarten Foundation |
    1000 Förderprogramm -
    1000 Fördernummer RFP05-14; RFP06-12
  7. 1000 joinedFunding-child
    1000 Förderer German Research Foundation |
    1000 Förderprogramm -
    1000 Fördernummer SI 1549/1-1
  8. 1000 joinedFunding-child
    1000 Förderer NIH |
    1000 Förderprogramm -
    1000 Fördernummer DK52913
  9. 1000 joinedFunding-child
    1000 Förderer l’Association pour la Recherche sur le Cancer |
    1000 Förderprogramm -
    1000 Fördernummer -
  10. 1000 joinedFunding-child
    1000 Förderer Fraternal Order of Eagles for Cancer Research |
    1000 Förderprogramm -
    1000 Fördernummer -
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6405716.rdf
1000 Erstellt am 2017-12-07T09:27:15.538+0100
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1000 beschreibt frl:6405716
1000 Bearbeitet von 218
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1000 Vgl. frl:6405716
1000 Oai Id
  1. oai:frl.publisso.de:frl:6405716 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
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