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WeightNameValue
1000 Titel
  • Caloric restriction and intermittent fasting alter hepatic lipid droplet proteome and diacylglycerol species and prevent diabetes in NZO mice
1000 Autor/in
  1. Baumeier, Christian |
  2. Kaiser, Daniel |
  3. Heeren, Jörg |
  4. Scheja, Ludger |
  5. John, Clara |
  6. Weise, Christoph |
  7. Eravci, Murat |
  8. Lagerpusch, Merit |
  9. Schulze, Gunnar |
  10. Joost, Hans-Georg |
  11. Schwenk, Robert Wolfgang |
  12. Schürmann, Annette |
1000 Erscheinungsjahr 2015
1000 Art der Datei
1000 Publikationstyp
  1. Artikel |
1000 Online veröffentlicht
  • 2015-01-31
1000 Erschienen in
1000 Quellenangabe
  • 1851(5): 566–576
1000 FRL-Sammlung
1000 Copyrightjahr
  • 2015
1000 Lizenz
1000 Verlagsversion
  • https://doi.org/10.1016/j.bbalip.2015.01.013 |
1000 Publikationsstatus
1000 Begutachtungsstatus
1000 Sprache der Publikation
1000 Abstract/Summary
  • Caloric restriction and intermittent fasting are known to improve glucose homeostasis and insulin resistance in several species including humans. The aim of this study was to unravel potential mechanisms by which these interventions improve insulin sensitivity and protect from type 2 diabetes. Diabetes-susceptible New Zealand Obese mice were either 10% calorie restricted (CR) or fasted every other day (IF), and compared to ad libitum (AL) fed control mice. AL mice showed a diabetes prevalence of 43%, whereas mice under CR and IF were completely protected against hyperglycemia. Proteomic analysis of hepatic lipid droplets revealed significantly higher levels of PSMD9 (co-activator Bridge-1), MIF (macrophage migration inhibitor factor), TCEB2 (transcription elongation factor B (SIII), polypeptide 2), ACY1 (aminoacylase 1) and FABP5 (fatty acid binding protein 5), and a marked reduction of GSTA3 (glutathione S-transferase alpha 3) in samples of CR and IF mice. In addition, accumulation of diacylglycerols (DAGs) was significantly reduced in livers of IF mice (P = 0.045) while CR mice showed a similar tendency (P = 0.062). In particular, 9 DAG species were significantly reduced in response to IF, of which DAG-40:4 and DAG-40:7 also showed significant effects after CR. This was associated with a decreased PKCε activation and might explain the improved insulin sensitivity. In conclusion, our data indicate that protection against diabetes upon caloric restriction and intermittent fasting associates with a modulation of lipid droplet protein composition and reduction of intracellular DAG species.
1000 Sacherschließung
lokal Fatty acid oxidation
lokal Lipid droplet proteome
lokal Intermittent fasting
lokal Diacylglycerol
lokal Insulin resistance
lokal Caloric restriction
1000 Fachgruppe
  1. Medizin |
  2. Ernährungswissenschaften |
1000 Fächerklassifikation (DDC)
1000 Liste der Beteiligten
  1. https://frl.publisso.de/adhoc/creator/QmF1bWVpZXIsIENocmlzdGlhbg==|https://frl.publisso.de/adhoc/creator/S2Fpc2VyLCBEYW5pZWw=|https://frl.publisso.de/adhoc/creator/SGVlcmVuLCBKw7ZyZw==|https://frl.publisso.de/adhoc/creator/U2NoZWphLCBMdWRnZXI=|https://frl.publisso.de/adhoc/creator/Sm9obiwgQ2xhcmE=|https://frl.publisso.de/adhoc/creator/V2Vpc2UsIENocmlzdG9waA==|https://frl.publisso.de/adhoc/creator/RXJhdmNpLCBNdXJhdA==|https://frl.publisso.de/adhoc/creator/TGFnZXJwdXNjaCwgTWVyaXQ=|https://frl.publisso.de/adhoc/creator/U2NodWx6ZSwgR3VubmFy|http://orcid.org/0000-0002-5860-606X|https://frl.publisso.de/adhoc/creator/U2Nod2VuaywgUm9iZXJ0IFdvbGZnYW5n|https://frl.publisso.de/adhoc/creator/U2Now7xybWFubiwgQW5uZXR0ZQ==
1000 Förderer
  1. German Federal Ministry of Education and Research (BMBF) |
  2. German Research Foundation (DFG) |
  3. European Union |
1000 Fördernummer
  1. 01GI0922
  2. SFB-958
  3. FP7-HEALTH-2012-305707
1000 Förderprogramm
  1. -
  2. -
  3. FP7: project RESOLVE
1000 Dateien
1000 Förderung
  1. 1000 joinedFunding-child
    1000 Förderer German Federal Ministry of Education and Research (BMBF) |
    1000 Förderprogramm -
    1000 Fördernummer 01GI0922
  2. 1000 joinedFunding-child
    1000 Förderer German Research Foundation (DFG) |
    1000 Förderprogramm -
    1000 Fördernummer SFB-958
  3. 1000 joinedFunding-child
    1000 Förderer European Union |
    1000 Förderprogramm FP7: project RESOLVE
    1000 Fördernummer FP7-HEALTH-2012-305707
1000 Objektart article
1000 Beschrieben durch
1000 @id frl:6405727.rdf
1000 Erstellt am 2017-12-07T14:52:54.615+0100
1000 Erstellt von 218
1000 beschreibt frl:6405727
1000 Bearbeitet von 218
1000 Zuletzt bearbeitet Tue Dec 11 14:00:42 CET 2018
1000 Objekt bearb. Tue Dec 11 14:00:42 CET 2018
1000 Vgl. frl:6405727
1000 Oai Id
  1. oai:frl.publisso.de:frl:6405727 |
1000 Sichtbarkeit Metadaten public
1000 Sichtbarkeit Daten public
1000 Gegenstand von

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